Colin Studholme

Research Interests

Developing and Applying Mathematical and Computational descriptions of anatomy from clinical imaging  to study brain development and aging

Research Summary

My research interests are in the area of computational imaging methods which bridge the gap between in-vivo brain imaging and the areas of neuroscience and clinical research. My current work focuses on developing and applying novel methodology to study variations and changes in brain anatomy at a macroscopic level from human imaging data. At the most basic level we are seeking to develop physically meaningful mathematical representations of brain structure which capture properties useful in clinical diagnosis, progression monitoring and fundamental neuroscience. Such work falls under the emerging field of computational anatomy.

For further details please see our website at:

http://radiology.ucsf.edu/bicg/

Selected Publications

C. E. Rodriguez-Carranza, P. Mukherjee, D. Vigneron, A. J. Barkovic, and C. Studholme, "A framework for in-vivo analysis of regional brain folding in premature neonates," Neuroimage, 2008, in press.

K. Strostrand, E. Rostrup, C. Ryberg, R. Larsen, C. Studholme, H. Baezner, J. Ferro, F. Fazekas, L. Pantoni, D. Inzitari, and G. Waldemar, "Sparse decomposition and modeling of anatomical shape variation," IEEE Trans. Med. Imaging, vol. 26, no. 12, pp. 1625-1635, December 2007.

V. A. Cardenas, A. L. Boxer, L. L. Chao, M. L. Gorno-Tempini, B. L. Miller, M. W. Weiner, and C. Studholme, "Deformation-based morphometry reveals brain atrophy in frontotemporal dementia," Arch. Neurol., vol. 64, no. 6, pp. 873-877, June 2007.

V. A. Cardenas, C. Studholme, S. Gazdzinski, T. C. Durazzo, and D. J. Meyerhoff, "Deformation-based morphometry of brain changes in alcohol dependence and abstinence," Neuroimage, vol. 34, no. 3, pp. 879-887, February 2007.

F. Rousseau, O. A. Glenn, B. Iordanova, C. E. Rodriguez-Carranza, D. B. Vigneron, A. J. Barkovich, and C. Studholme, "Registration-based approach for reconstruction of high-resolution in utero MR brain images," Acad. Radiol., vol. 13, no. 9, pp. 1072-1081, September 2006.

B. Iordanova, D. Rosenbaum, D. Norman, M. W. Weiner, and C. Studholme, "MRI study of neurodegeneration: A robust volumetric parcellation method of the frontal lobe gyri with quantitative validation in dementia patients," Am. J. Neuroradiol., vol. 27, no. 8, pp. 1747-1754, September 2006.

C. Studholme, C. S. Drapaca, B. Iordanova, and V. A. Cardenas, "Deformation-based mapping of volume change from serial brain MRI in the presence of local tissue contrast change," IEEE Trans. Med. Imaging, vol. 25, no. 5, pp. 626-639, May 2006.