Dorian Liepmann

Professor, Bioengineering and Mechanical Engineering Core Member, UCB/UCSF Graduate Group in Bioengineering 280 Hearst Memorial Mining Building mailcode: MC 1762 fax: (510) 642-5835 This e-mail address is being protected from spambots. You need JavaScript enabled to view it http://www.me.berkeley.edu/~liepmann/ Membership effective July 1993

Research Interests

BioMEMS, microfluid dynamics, experimental biofluid dynamics, hemodynamics associated with valvular heart disease and other cardiac and arterial flows.

Research Summary

I work in the area of BioMEMS, specifically on the application of micro - machined or fabricated devices for the investigation, diagnosis, or cure of medical and biological problems. MEMS devices are revolutionary because their small size (on the order of 10 - 100 microns, with features as small as 10 nanometers) not only reduces the size of current devices but makes entirely new procedures and paradigms possible from distributed micro-sensor systems to new drug delivery systems. Most of my research is focused on micro-fluid dynamics, but this includes design of new fluidic control systems.

Fundamental studies on the fluid mechanics of complex biological fluids in MEMS devices, this project includes work with LLNL on two-phase flows and a project on dielectrophoresis. Development of numerical tools for the design of micro-fluidic systems. Investigation of insect flight and control dynamics (with Michael Dickinson and Andy Packard). Other projects (non-Bio) include development of micro-heat removal devices and a micro-wankel engine.

Selected Publications

    Stoeber B, Hu CMJ, Liepmann D, Muller SJ, “Passive flow control in microdevices using thermally responsive polymer solutions.” Physics of Fluids 18(5): 2006.
    Chang WC, Lee LP, Liepmann D, "Biomimetic technique for adhesion-based collection and separation of cells in a microfluidic channel," Lab on a Chip 5(1) 64-73, 2005.
    Stoeber B, Liepmann D. “Arrays of hollow out-of-plane microneedles for drug delivery,” Journal of Microelectromechanical Systems 14(3) 472-9, 2005.
    Sivamani RK, Stoeber B, Wu GC, Zhai H, Liepmann D, Maibach H. “Clinical microneedle injection of methyl nicotinate: stratum corneum penetration.” Journal of Skin Research and Technology, 11:152-156, 2005
    Zimmermann S. Fienbork D. Flounders AW. Liepmann D. “In-device enzyme immobilization: wafer-level fabrication of an integrated glucose sensor.” Sensors & Actuators B-Chemical. 99(1):163-173, 2004
    Zahn JD, Deshmukh A, Pisano AP, Liepmann D. “Continuous on-chip micropumping for microneedle enhanced drug delivery,” Biomedical Microdevices. 3:183-90, 2004