Han Lim| | Assistant Professor, Integrative Biology
Affiliate, UCB/UCSF Graduate Group in Bioengineering 4094 Valley Life Sciences Building
mailcode: MC 3140
(510) 643 5915
fax: (510) 643 1148
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http://ib.berkeley.edu/labs/lim/ Membership effective July 2007 |
Research Interests Design, properties and evolution of genetic circuits. Epigenetic and RNA control of cell differentiation. Research Summary
The Lim Lab studies the design, properties and evolution of genetic circuits. We are particularly interested in genetic circuits that regulate the amount of phenotypic diversity ("noise") in populations of genetically identical cells. Much of work focuses on systems involved in bacterial survival and pathogenesis with the aim of providing new strategies to combat infectious disease. Our research examines mechanisms at the molecular, cellular, population and ecological levels using a combination of theoretical and experimental approaches. Current areas of interest include: the role of genetic noise in regulating diversity biological systems, epigenetic control of gene expression; information processing at cis-regulatory sequences; and RNA signalling cascades.
Selected Publications
Lim HN, van Oudenaarden A. A multistep epigenetic switch enables the stable inheritance of DNA methylation states. Nat Genet. 2007;39:269-75.
Ozbudak EM, Thattai M, Lim HN, Shraiman BI, Van Oudenaarden A. Multistability in the lactose utilization network of Escherichia coli. Nature. 2004;427:737-40.
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