Luke Lee

Professor, Bioengineering Director, Biomolecular Nanotechnology Center and Berkeley Sensor & Actuator Center Core Member, UCB/UCSF Graduate Group in Bioengineering 408C Stanley Hall mailcode: MC 1762 (510) 642-5855 fax: (510) 642-5835 This e-mail address is being protected from spambots. You need JavaScript enabled to view it http://biopoets.berkeley.edu Membership effective July 2000

Research Interests

The BioPOETS (Biologically-inspired Photonics & Optofluidic Electronics Technology and Science) group is focusing on quantum nanoplasmonics for in vivo molecular and cellular imaging; microfluidic cellular BASICs (Biological Application Specific Integrated Circuits) for quantitative cell biology; soft-state biological devices for single cell biophysics; nanobiotechnology for molecular diagnostics; BioMEMS and BioPOEMS (Biomolecular Polymeric Opto-Electro Mechanical Systems) for the digitalization of quantitative systems biology, systematic neuroscience, and molecular medicine.

Research Summary

The BioPOETS (Biologically-inspired Photonics & Optofluidic Electronics Technology and Science) group is focusing on quantum nanoplasmonics for in vivo molecular and cellular imaging; microfluidic cellular BASICs (Biological Application Specific Integrated Circuits) for quantitative cell biology; soft-state biological devices for single cell biophysics; nanobiotechnology for molecular diagnostics; BioMEMS and BioPOEMS (Biomolecular Polymeric Opto-Electro Mechanical Systems) for the digitalization of quantitative systems biology, systematic neuroscience, and molecular medicine.

Selected Publications

    Luke P. Lee and Robert Szema, “Inspirations from Biological Optics for Advanced Photonic Systems,” Science, 310, 1148 – 1150 (2005).
    Cristian Ionescu-Zanetti, Robin M. Shaw, Jeonggi Seo, Yuh-Nung Jan, Lily Y. Jan, and Luke P. Lee, “Mammalian Electrophysiology on a Microfluidic Platform,” Proc. Natl. Acad. Sci. USA, 102, 9112-9117(2005).
    Yu Lu, Gang L. Liu, Jay Kim, Yara X. Mejia, and Luke P. Lee, “Nanophotonic Crescent Moon Structures with Sharp Edge for Ultrasensitive Biomolecular Detections by Local Electromagnetic Field Enhancement Effect,” Nano Letters, 5(1), 119-124 (2005).
    Ki-Hun Jeong, Jaeyoun Kim, Luke P. Lee, “Biologically Inspired Artificial Compound Eyes,” Science, 312, 557-561 (2006).
    Gang L. Liu, Jaeyoun Kim, Yu Lu, and Luke P. Lee, “Optofluidic Control Using Photothermal Nanoparticles,” Nature Materials, 5, 27-32 (2006).
    Gang L. Liu, Yadong Yin, Siri Kunchakarra, Bipasha Mukherjee, Daniele Gerion, Stephen D. Jett, David G. Bear, Joe W. Gray, A. Paul Alivisatos, Luke P. Lee, and Fanqing Frank Chen, "A Nanoplasmonic Molecular Ruler for Measuring Nuclease Activity and DNA Footprinting," Nature Nanotechnology, 1, 47-52 (2006).
    Dino Di Carlo and Luke P. Lee, “Dynamic Single Cell Analysis for Quantitative Biology,” Anal. Chem., 7918-7925 (2006).
    Philip J. Lee, Paul J. Hung, Vivek M. Rao, Luke P. Lee, “Nanoliter Scale Microbioreactor Array for Quantitative Cell Biology,” Biotechnology & Bioengineering, 94 (1), 5-14 (2006).
    David N. Breslauer, Philip J. Lee, and Luke P. Lee, “Microfluidic-based Systems Biology,” Molecular BioSystems, 2, 97-112 (2006).
    Philip J. Lee, Paul J. Hung, and Luke P. Lee, "An Artificial Liver Sinusoid with a Microfluidic Endothelial-like Barrier for Primary Hepatocyte Culture," Biotechnology and Bioengineering (2007).