Mark D'Esposito

Research Interests

My research focuses on investigating the neural bases of high-level cognitive processes such as working memory, as well as the development of functional MRI methodology.

Research Summary

My research focuses on investigating the neural bases of high-level cognitive processes such as working memory and executive control. These aims are achieved through several different experimental approaches and methodologies. First, we employ a neuroimaging method called functional MRI (fMRI) to identify the neuroanatomical substrates and temporal dynamics of various cognitive processes in normal human subjects. A key focus has been the cognitive functions supported by prefrontal cortex. Second, we have been investigating the role of the dopaminergic system in working memory and frontal lobe function. This aim is achieved with pharmacological studies during which direct dopaminergic agonists are administered to normal human subjects, as well as patients with frontal lobe lesions, to determine the effect of dopamine on cognition. Third, we perform behavioral studies in patient populations with frontal lobe dysfunction (e.g. stroke, head injury, Parkinson's disease) in order to further understand the mechanisms that underlie working memory. Fourth, we are interested in understanding the physiological bases of normal human aging, and the effects of normal aging on prefrontal function. Finally, my lab is actively involved in developing new methods in experimental design and statistical analysis of fMRI data.

Selected Publications

D'Esposito M, Zarahn E, Aguirre G. Event-related fMRI: implications for cognitive psychology, Psychological Bulletin, 125:155-164, 1999.

D'Esposito M, Postle BR, Rypma B. Prefrontal cortical contributions to working memory: Evidence from event-related fMRI studies, Experimental Brain Research, 133:3-11, 2000.