Pratik Mukherjee

Research Interests

My research focus is on technical development and clinical application of advanced diffusion MRI methods, including diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI). Recent work includes ultra-high field (7 Tesla) diffusion MRI and the application of DTI/HARDI to the study of cerebral connectivity in human brain development and traumatic brain injury.

Research Summary

My research focus is on technical development and clinical application of advanced diffusion MRI methods, including diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI) techniques such as q-ball imaging. Recent work in collaboration with the laboratory of Dr. Daniel B. Vigneron includes the initial application of ultra-high field (7 Tesla) diffusion MRI to the study of the complex white matter architecture of the human brain in vivo. I also currently have ongoing prospective longitudinal clinical research studies of DTI, HARDI, and related fiber tractography techniques for evaluating changes in white matter connectivity during human brain development and following traumatic brain injury.

Selected Publications

P. Mukherjee, J.H. Miller, J.S. Shimony, T.E. Conturo, B.C.P. Lee, C.R. Almli, R.C. McKinstry.  Normal brain maturation during childhood: developmental trends characterized with diffusion-tensor MR imaging.  Radiology, 2001.

P. Mukherjee, J.H. Miller, J.S. Shimony, J.V. Philip, D. Nehra, A.Z. Snyder, T.E. Conturo, J.J. Neil, R.C. McKinstry.  Diffusion-tensor MR imaging of gray matter and white matter development during normal human maturation.  AJNR Am J Neuroradiol, 2002.

L.C. Maas, P. Mukherjee, J. Carballido-Gamio, S. Veeraraghavan, S.P. Miller, S.C. Partridge, R.G. Henry, A.J. Barkovich, D.B. Vigneron.  Early laminar organization of the developing human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants.  Neuroimage, 2004. 

A.R. deIpolyi, P. Mukherjee, K.R. Gill, R.G. Henry, S.C. Partridge, S. Veeraraghavan, H. Jin, Y. Lu, S.P. Miller, D.M. Ferriero, D.B. Vigneron, A.J. Barkovich.  Comparing microstructural and macrostructural development of the cerebral cortex in premature newborns:  Diffusion tensor imaging versus cortical gyration.  Neuroimage, 2005.

C.P. Hess, P. Mukherjee, E.T. Han, D. Xu, D.B. Vigneron.  Q-ball reconstruction of multimodal fiber orientations using the spherical harmonic basis.  Magn Reson Med, 2006.