Circulating tumor cells (CTCs) are detached primary cancer cells found in the circulatory system that are implicated in the metastasis of cancer. Herr and collaborators have developed a microfluidic western blot for an 8-plex protein panel for individual CTCs, derived from estrogen receptor positive breast cancer patients, that advances the state of the art in CTC characterization with tiny sample sizes.
Herr Lab advances protein expression profiling of circulating tumor cells using microfluidic western blotting
A recent proof-of-concept study shows that a tiny portable microjet injector called MucoJet can deliver a high-pressure stream of liquid and immune system-triggering molecules that penetrate the mucosal layer of the mouth to stimulate an immune response in the buccal region. The jet is pressurized, but not uncomfortably so, and would remove the sting of needles. Postdoctoral scholar Kiana Aran is lead investigator on the study.
New research from Professor Sanjay Kumar’s lab uncovers fundamental design principles of how cells and tissues define and maintain their structure, combining sophisticated micropatterning technologies to engineer cell shape, laser nanosurgery to cut individual stress fibers with light and probe their internal structure, and mathematical modeling. Cell shape is critical in development, wound healing, stem cell differentiation, and cancer, among other processes. The lead author is bioengineering PhD student Elena Kassianidou .
Professor Adam Arkin will lead the new NASA Center for the Utilization of Biological Engineering in Space (CUBES), a Space Technology Research Institute to advance research into an integrated, multi-function, multi-organism bio-manufacturing system to produce fuel, materials, pharmaceuticals and food on long-term space missions.
The Chan Zuckerberg Biohub has announced it’s inaugural class of 47 faculty investigators from UC Berkeley, UCSF and Stanford, including three Berkeley Bioengineers. Professors Dan Fletcher, Amy Herr and Aaron Streets are among the 13 Berkeley faculty who will receive up to $1.5 million each over the next five years to conduct cutting-edge biomedical research.
Professor Steven Conolly’s lab has won the 2017 Excellence in Laboratory Safety Award in the Large Physical Sciences Lab category. Winners were selected based on consideration of the lab’s safety inspection results, internal safety communications, and collaboration with EH&S and Department Safety Coordinators.
Lawrence Berkeley National Lab began construction of the Integrative Genomics Building (IGB), which will house researchers from the Department of Energy Joint Genome Institute with those from the Systems Biology Knowledgebase under one roof. Bioengineering professors Adam Arkin, Director of Kbase, and Jay Keasling, Biosciences Associate Laboratory Director, were on hand for the groundbreaking.
Research from Professor Mohammad Mofrad’s lab, “Bacterial Networks on Hydrophobic Micropillars”, made the cover of the journal ACS Nano this issue.
Healy Lab’s heart-on-a-chip technology is the subject of a video feature at Futurism.
Bioengineering MEng students Sneha Balan and Nick Engel are featured on page 4 of the Winter MEng newsletter, for their Early Cancer Detection project and Alumni Innovation Award. Nick is also on the cover.
After severe trauma, some patients in shock develop impaired coagulation. This is difficult to diagnose in crisis and makes blood transfusions dangerously challenging to manage. Professor Adam Arkin and collaborators have used dynamic modeling to demonstrate a method for calculating each patient’s transfusion requirements using only laboratory values that can be easily and quickly obtained in the emergency setting. This personalized information could help hospitals save lives at risk from acute traumatic coagulopathy and massive transfusion mortality.
For the #1 spot in their annual Top 10 Innovations of the year, The Scientist magazine has chosen Milo, the commercial version of the single-cell Western blot technology invented in Professor Amy Herr’s lab. Originally developed for market by BioE PhD alumna Kelly Gardner for their startup Zephyrus Biosciences, acquired by BioTechne, Gardner now runs commercialization of the product for ProteinSimple.
The CellScope, a cellphone-based microscope from Professor Dan Fletcher’s lab, was featured in the latest issue of the Berkeley Science Review.
A new study from Professor Irina Conboy’s lab found that tissue health and repair dramatically decline in young mice when half of their blood is replaced with blood from old mice. This adds further detail to the complex study of aging and suggest that young blood alone will not reverse the aging process.
Check out this great video on the CellScope Loa.