To develop useful in vitro model systems for identifying the correlation between genetic deficiencies and environmental stress for cardiomyopathy, Professor Kevin Healy and his lab teamed up with molecular biologists at the Gladstone Institute of Cardiovascular Diseases to combine cutting edge tissue engineering and genome editing techniques to create a “diseased heart micro-tissue” model to mimic both the genetic and physical components of cardiomyopathy.
Researchers led by BioE PhD student Shakked Halperin, working in the laboratories of David Schaffer and John Dueber at UC Berkeley, have described yet another creative application for CRISPR: a platform to spur evolution of specific genes inside cells.
Macrophages are the body’s immune attack force, but how do they recognize their target particles? Fletcher Lab investigators have shown how macrophage target recognition is controlled by the height of the antibody above the target cell surface. They found that the gap created between the target cell and macrophage by the antibody, which bridges an antigen on the target cell surface and the macrophage’s receptors, must be small enough to exclude a molecule that turns off the receptor. This has broad implications for development of therapeutic antibodies because it establishes a size threshold for effective cell surface antigen targets.
New research from Prof Niren Murthy’s lab uses his CRISPR-Gold nanoparticle delivery technique to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known single-gene cause of autism spectrum disorder. Published in Nature Biomedical Engineering June 25, 2018.
Professor Adam Arkin co-authors the largest functional genomics study of bacteria ever published. He and collaborators have developed a workflow that enables large-scale, genome-wide assays of gene importance across many conditions.
Bioengineering PhD alumni Nick Fawzi and Sapun Parekh started a conversation about something completely different and ended up with a grant from the Human Frontier Science Program to study membraneless organelles.
Professor Amy Herr and her lab are highlighted in this Nature Methods Technology Feature, exploring new ways to for researchers to share designs, devices and experience.
Professors Sanjay Kumar and Kevin Healy, in collaboration with Professor of Nutritional Sciences and Toxicology Andreas Stahl, have discovered that the same kind of fat cells that help newborn babies regulate their body temperature could be a target for weight-loss drugs in adults.
BioE startup GenEdit is featured in Wired as the first company devoted solely to Crispr delivery.