2011 Capstone teams

Team DelDect

Project & Title:  SqueakPeak: Mouse Pup Birth Detector for Research Laboratories

Team Members: Alexsandra Denisin, Davis Li, Pauline Luong, Chris Alabastro

Capstone Client: David Copenhagen, Ph.D, UCSF Opthalmology & Physiology

Purpose: Development studies of synaptic pathways in mouse neonatal retina, phototaxis, and hyaloid vessel regression currently require that mice are dark reared. To achieve this, pregnant mice are isolated from other mice 2-3 days before litter birth. Pup age is estimated by manual inspection that requires a laboratory professional to check on the mice daily, including after normal business hours. The Capstone team developed a pup delivery detector to accurately determine birth time of pups such that researchers can age-match mice. Unlike manual inspection, this research sensor identifies the birth hour and day for age-matching individuals.

deldect concept

Concept schematic of the automated birth date and time detection and monitoring system for research on development of neonatal retina, phototaxis, and hyaloid vessel regression.


hand-held IVF device

Rendering of the hand-held IVF device, allowing high precision and accuracy deposition of an embryo to specific locations in the uterus.

Team E Gen

Project & Title: Embryo Delivery Device for Greater In Vitro Fertilization Success

Team Members: Wanging Du, Vincent Liu, Pamela Tiet, Hanson Zhao

Capstone Client: Paolo Rinaudo, M.D., Ph.D., Assistant Professor & Practicing Clinician at UCSF School of Medicine

Purpose/Goal: In vitro fertilization (IVF) involves fertilization of a human embryo outside the body in an artificial environment. The typical success rate for IVF ranges widely – from 10% to 60% — depending on the female’s age, clinic, and physician. Procedures can cost several thousand dollars. To address the IVF success rate variability, the Capstone team developed a hand-held device to enable high accuracy and precision delivery of an embryo to specific locations in the uterus, as is needed in IVF.

 


EPT prototype

Functional prototype and concept schematic of patient transfer device (1:3 scale model)EPT diagram

Team EPT

Project & Title: Transforming Patient Handling

Team Members: Bryant Chu, Hoaming Huang, Eric Johnson, Jessie Tung

Capstone Client: David Rempel, M.D., Ph.D., UC Berkeley

Purpose/Goal: Current methods of patient transfer create immediate and long-term safety concerns for both the patient and healthcare professionals. Immediate risk involves injury to the patient during a transfer while long-term risk concerns injury to the caregiver from manual handling. To address rising injury rates with an aging population, this Capstone team developed a safer, more efficient system to move hospital patients to and from beds/tables to minimize risk of injury to both the patient and caregiver.

 


FeBenders prototype

Functional prototype of cell phone based imaging for anemia assessment of blood spots using WHO diagnostic standards.

Team FeBenders

Project & Title: Portable Assessment of Hemoglobin Levels in Resource Poor Settings

Team Members: Philippe Decorwin-Martin, Austin Kwong, Xin Xin Lin, Nawal Siddiqui

Capstone Clients:  Megan Huchko, M.D., M.P.H Advisor for Jacaranda Health; Nick Pearson, Founder and managing Director for Jacaranda Health

Purpose: Jacaranda Health is a mobile maternity clinic serving rural & urban communities in Kenya. One dysfunction relevant to Jacaranda’s mission is to diagnose and treat anemia. Anemia is characterized by a decrease in red blood cells or a low level of hemoglobin in the blood and leads to an annual death toll of almost a million deaths. The Capstone team worked with Jacaranda Health to create portable means to accurately assess human hemoglobin levels in a resource-limited setting using commonly available mobile telephone technology and WHO anemia standards.

Process for FeBenders

 


Nebulizer diagram

Rendering of integrated asthma monitoring device for at-home monitoring of asthmatic flares.

Team Nebulizer

Project & Title: A Home Monitoring: Early Detection of Asthma Flares

Team Members: Charvi Shetty, Vinidhra Mani, Jay Kumar

Capstone Client: John Hixson, M.D. Clinical Neurologist, Assistant Professor at UCSF; Pulmonary Function Test Lab, UCSF Medical Center

Purpose: Asthma, a disorder causing airway constriction, affects 34.1 million people in the United States. Asthma is a degenerative, heterogeneous disorder with varied triggers. Clinically, asthma is subject to grossly generalized treatments. Through extensive needs finding, the Capstone team identified a need for a non-invasive, consistent monitoring of a patient’s asthmatic flares to inform specific courses of treatment. The team introduced an in-home, portable asthma monitoring device with components for airflow and chemical measurement.


Newborn setup

Functional prototype employs small pressure sensors mounted in a flexible sheath to continuously collect pressure at selected points around the nipple. Real time pressure values and target ranges are displayed for the physician to interpret.newborn sensor

Team Newborn

Project & Title: Improve Breastfeeding Latching Assessment

Team Members: Saba Khalilmaji, Brian McRae, Chengwin Saephanh, Libing Wang

Capstone Client: Carol Miller, M.D., UCSF Pediatric specialist for well–born neonates, Francis Kong, Graduate from the University of Missouri School of Medicine; Barbara Gay, RN, UCSF lactation consultant

Purpose/Goal: Breastfeeding is essential for the development of newborns. Tongue tied, sore nipples, and incorrect positioning may contribute to unsuccessful breastfeeding session. The Capstone team created an electronic sensing device for direct and continuous assessment of breastfeeding mechanisms as a means to aid physicians in correcting nonproductive behaviors.


RAJE device design

Rendering of sputum preparation kit for subsequent sample mounting on microscope slides.

Team RAJE

Project & Title: Point of Care CellScope Diagnostics for Tuberculosis

Team Members: Raymond Lee, Aleo Mok, Jessica Wen, Elaine Su

Capstone Clients: Asa Tapley, UCSF School of Medicine, UC Berkeley School of Public Health Joint Program; Lina Nilsson, Ph.D., UC Berkeley

Purpose: Tuberculosis is a bacterial infection that afflicts 9 million new individuals per year. In conjunction with the CellScope team at UC Berkeley, this Capstone team developed a low-cost, portable device to generate consistent and high-quality sputum samples for the diagnosis of tuberculosis via cell phone based imaging.

 


branched catheter prototype

functional prototype of a branched thoracic catheter to allow more efficient hemothorax drainage after thoracostomy

Team Thorax

Project & Title: The Branched Thoracic Catheter; Efficient Hemothorax Drainage Through Localization Targeting

Team Members: Gary Chan, Albert Lan, Kathleen Lo, Tiffany Truong

Capstone Clients:  Rais Vohra, M.D., UCSF – Fresno Emergency Medicine Physician; Steven Cheung, M.D., UCSF Head and Neck Surgeon

Purpose: Thoracostomy procedures involve an incision made into the chest wall to provide an opening for drainage via a chest tube. The flexible plastic tube removes fluid or air from the pleural cavity, but the drainage location is currently limited to one area within the pleural cavity. The Capstone team introduced a device that allows for constant drainage of a hemothorax in trauma patients requiring a thoracostomy.

thorax rendering