Spring 2013 Bioengineering Seminar Series
Wednesdays, 12:00 noon-1:00 pm, 106 Stanley Hall
Our next seminar:
Richard M. Murray
Control and Dynamical Systems
California Institute of Technology
“Biomolecular Breadboards for Prototyping and Debugging Synthetic Biocircuits”
We are developing a set of “biomolecular breadboards” to create a systematic, engineering-oriented approach to synthesizing biomolecular circuits that involves developing, modeling, and debugging a sequence of prototype devices, each at increasing levels of complexity and each allowing the incorporation of increasingly realistic operating environments for either in vitro or in vivo applications. Our goal is to reduce the iteration time for multiple prototype circuit designs to no more than a day and to design and implement novel, working circuits in cells in as little as a week. We are currently making use of three breadboard technologies: transcription systems for design of “genelet” circuits, cell-free extracts that can implement many of the core processes present in prokaryotic cells, and DNA origami as a substrate for exploring the effects of spatial localization. I will briefly describe each of these technologies and summarize some of our recent results in modeling, prototyping, debugging and implementing biocircuits using these breadboards.
Hosted by Professor John Dueber
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