BioE Seminars

Spring 2017 Bioengineering Seminar Series

Wednesdays, 12:00 noon-1:00 pm
290 Hearst Memorial Mining Building
(please note NEW ROOM LOCATION)

Next Seminar:

Princess Imoukhuede
Assistant Professor of Bioengineering
University of Illinois — Urbana Champaign

Wednesday, February 22
12noon – 1:00pm
290 Hearst Mining Building

Title:
Peering into the “black-box” of protein signaling: quantifying protein-protein interaction kinetics and protein concentrations to computationally predict cell response?

Abstract:
Directed control of angiogenesis can improve the treatment of over 70 diseases. Understanding how to control angiogenesis can be achieved by deterministic computational modeling that both mathematically describes angiogenic signaling pathways and simulates how these pathways will respond to biological perturbations. Towards this goal, we have arrived at three key advancements: (1) development of multiplexed fluorescent sensors of angiogenic protein concentrations, (2) discovery and measurement of new protein-protein interaction (PPI) kinetics; and (3) computational simulation of angiogenic signaling, which predicts VEGFR-mediated second messenger phosphorylation, cell proliferation, and cell migration.

Our approaches are advancing us towards the much needed goal of directed angiogenic control. Firstly, our multiplexed fluorescence sensors are establishing a new method for quantifying angiogenesis biomarkers, which can be translated to clinical pathology. More immediately, this approach is providing the receptor concentration data necessary for accurate computational model development. Additionally, our discovery and measurement of novel PPIs represents a paradigm shift, where kinetics, not protein family, defines our view of protein function. More immediately, these kinetic measurements provide the necessary data for predictive modeling. Finally, our computational models are integrating each of the aforementioned parameters and providing validated predictions of angiogenic cell response.

This material is based upon work supported by the National Science Foundation under Grant #1512598. This work was also supported by American Heart Association Grant #16SDG26940002.

Hope to see you there!


Upcoming seminars:

March 1 Ashleigh Theberge
Assistant Professor of Chemistry
University of Washington
March 8 Ngan Huang
Assistant Professor of Cardiothoracic Surgery
Stanford University
March 15
*Sibley Auditorium
Dino DiCarlo
Professor of Bioengineering
UCLA
March 22 Chris Vollmers
Assistant Professor of Biomolecular Engineering
UC Santa Cruz
March 29 NO SEMINAR due to Spring Recess
April 5 Kandice Tanner
Chief, Tissue Morphodynamics Unit
National Institutes of Health
April 12 Polly Fordyce
Assistant Professor of Genetics and Bioengineering
Fellow, ChEM-H Institute
Stanford University
April 19 Ahmad (Mo) Khalil
Innovation Career Development Professor
Assistant Professor of Biomedical Engineering
Associate Director, Biological Design Center
Boston University
April 26 Patrick Stayton
Professor of Bioengineering
University of Washington
May 3 TBA


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View a list of past seminar speakers