Bioinstrumentation is the development of technologies for the measurement and manipulation of parameters within biological systems, focusing on the application of engineering tools for scientific discovery and for the diagnosis and treatment of disease. Examples include instrumentation for imaging, disease diagnosis, and therapeutics.
Two important challenges in which many of our faculty are engaged are the miniaturization of traditional bioinstrumentation for consideration of single cells or microscale tissues, and the adaptation of traditional bioinstrumentation for distribution and deployment outside traditional care environments, such as the home and resource-poor settings.
Faculty working in bioinstrumentation:Thomas Budinger
Professor Emeritus, Bioengineering
Professor Emeritus, Electrical Engineering & Computer Science, UCB
Professor Emeritus, Radiology, UCSF
Medical imaging instrumentation and data analysis methods development are the main focus of research from the standpoints of innovations and new techniques. Human physiology investigations using tools of imaging and wireless biomonitoring is a secondary focus.
Assistant Professor, Bioengineeringhttp://clarklab.berkeley.edu/
The Clark Lab develops microfluidic and molecular methods for the high throughput analysis of single cells. We use these techniques to study HIV latency in CD4 T cells and profile cellular interactions during central nervous system inflammation.
Montford G. Cook Professor, Bioengineering
Professor, Electrical Engineering & Computer Sciences
The Conolly Lab has built the world’s highest spatial resolution MPI scanner and the only projection MPI scanner in the world. In addition, the lab has built the only 3D Projection-Reconstruction MPI scanner currently in existence.
Professor in Residence, Department of Bioengineering
Professor and Chair, Bioengineering and Therapeutic Sciences, UCSF
Dr. Desai’s lab focuses in the area of biomedical micro and nanotechnology for therapeutic delivery. Professor Desai’s research spans multiple disciplines including materials engineering, cell biology, tissue engineering, and drug delivery.
Daniel A. Fletcher
Purnendu Chatterjee Chair in Engineering Biological Systems, Bioengineering
Faculty Scientist, Lawrence Berkeley National Laboratory
The Fletcher Lab develops diagnostic technologies and studies mechanical regulation of membrane and cytoskeleton organization in the context of cell motility, signaling, and host-pathogen interactions. We specialize in development of optical microscopy, force microscopy, and microfluidic technologies to understand fundamental organizational principles through both in vitro reconstitution and live cell experiments. Recent work includes investigating the mechano-biochemistry of branched actin network assembly with force microscopy, studying membrane deformation by protein crowding and oligomerization with model membranes, and reconstituting spindle scaling in encapsulated cytoplasmic extracts. The long-term goal of our work is to understand and harness spatial organization for therapeutic applications in cancer and infectious diseases.
Amy E. Herr
John D. & Catherine T. MacArthur Professor, Bioengineering
Faculty Scientist, Biological Systems & Engineering Division, LBNL
Faculty Director, UC Berkeley Bakar Fellows Program and Bakar BioEnginuity Hub
Use of scale-dependent phenomena to design tools for quantifying biomolecules in complex biological fluids down to single cell and sub-cellular resolution. Applications include clinical diagnostics, protein signaling + biomarker validation.
Bioengineering and Electrical Engineering & Computer Sciences
Dr. Lee’s research interests are biophotonics, quantum nanoplasmonics, in-vivo nanoscopy, single cell biophysics, quantitative systems biology, SERS, molecular diagnostics, BioMEMS, soft-state Biological Application Specific Integrated Circuits (BASICs), neural interfaces, and systematic neurological science and engineering by Biologically-inspired Photonics & Optofluidic Electronics Technology and Science (BioPOETS).
Professor, Mechanical Engineering
BioMEMS, microfluid dynamics, experimental biofluid dynamics, hemodynamics associated with valvular heart disease and other cardiac and arterial flows.
The Marriott Lab operates at the interface of chemistry, biology, medicine and engineering, is focused on understanding the molecular regulation of cellular processes and function, and improving human health. Active research projects underway in my group include establishing new principles and techniques for high-contrast imaging and optical manipulation of specific proteins in living cells and tissue, developing new smart biomaterials that mimic the extracellular organisms. The ultimate goal of these studies is to understand the molecular regulation of specific processes within living systems over multiple scales of biological organization, space and time, and to use this knowledge to develop drugs and therapies to improve human health.
Professor, Mechanical Engineering
Faculty Scientist, Lawrence Berkeley National Lab
Our research program is focused on understanding cell mechanobiology and molecular mechanisms involved in human disease, in particular cardiovascular dysfunctions, brain and neurological disorders, and cancer.
Professor Emeritus, Bioengineering
Professor of the Graduate School, Mechanical Engineering
Bioelectronic devices, biotransport, medical imaging, electrical impedance tomography.
S. Shankar Sastry
Thomas Siebel Professor of Bioengineering, Electrical Engineering and Computer Sciences, and Mechanical Engineeringhttps://robotics.eecs.berkeley.edu/~sastry
Assistant Professor, Bioengineeringhttps://streetslab.com/
The Streets lab is interested in applying lessons from mathematics, physics, and engineering, to invent tools that help us dissect and quantify complex biological systems. Our goal is to uncover laws that govern the interactions of molecules inside the cell and the interactions between cells in a tissue or organism, by making precision measurements on single cells. In pursuit of this goal, we exploit three core technologies; microfluidics, microscopy, and genomics.
Assistant Professor, Bioengineering
Assistant Professor, Helen Wills Neuroscience Institute
Assistant Professor, Berkeley Nanosciences and Nanoengineering Institute
Our lab seeks to understand the neural basis of complex spatial and acoustic behaviors. We advance and develop technologies for studying neural activity in freely behaving and flying bats and apply those to our investigation of their neural circuits. An example is our recent development of methods for wireless recording of neural activity from freely flying bats. We plan to develop technologies for optogenetic control and imaging of neural activity in freely behaving and apply these tools in our studies. We aim to uncover basic principles of brain function that are general across mammals.