Wednesdays, 12:00 -1:00 PM
106 Stanley Hall
Wednesday, September 27
12noon – 1:00pm Pacific Time
Stanley Hall, Room 106
or Register for Zoom link here: https://berkeley.zoom.us/webinar/register/WN_GqCr5tIDRw2fL9a4BDurqg
“Bioengineering Kidney Replacement Technology for Chronic Renal Failure”
Dr. Shuvo Roy
Professor, Department of Bioengineering & Therapeutic Sciences
Director, Biodesign Laboratory
Technical Director, The Kidney Project
Faculty Director, Master of Translational Medicine Graduate Program
UCSF-UC Berkeley Joint Graduate Group in Bioengineering
UCSF Schools of Pharmacy and Medicine
More than 800,000 Americans and 3 million people worldwide receive treatment for end-stage renal disease (ESRD). While kidney transplantation offers excellent outcomes, the supply of donor organs is severely limited, and less than 20% of patients waiting for a transplant ever receive one. For the vast majority of ESRD patients, in-center dialysis is the only treatment option. Unlike healthy kidneys, which function continuously, in-center dialysis is provided in short bursts of treatment, typically 3-5 hour sessions 3 times per week, during which the blood is pumped through an external circuit to filter out harmful toxins. Patient mortality after 1 year of treatment averages 20% and rises to nearly 60% after 5 years. Dialysis is also extremely expensive, costing Medicare almost $90,000 per patient per year.
The Kidney Project is developing a surgically implantable, self-monitoring, and self-regulating bio-artificial kidney to perform key functions of the natural kidney. The device is powered by the body’s blood pressure without external connections and without the need for anticoagulants or immunosuppressant drugs. The bioartificial kidney consists of a compact hemofilter comprised of biocompatible silicon nanopore membranes for ultrafiltration of blood, and an immunoprotected renal tubule cell bioreactor that reabsorbs salts and water to ensure volume homeostasis. The device will serve as a universal donor kidney that will overcome the shortage of donor kidneys, improve health outcomes of patients, and save costs for Medicare. This talk will describe the scientific and clinical foundations for the design of device, fundamental technology advancements, and current status of development in preclinical testing.