Spring 2023
Wednesdays, 12:00 -1:00 PM
290 Hearst Memorial Mining Building
Wednesday February 22
2022-23 Rising Star speaker
Polly Fordyce
Associate Professor of Bioengineering and of Genetics, Fellow of the ChEM-H Institute, Stanford University
Details TBA
Wednesday, March 1
12noon – 1:00pm
290 Hearst Mining Building
or Register for Zoom link here:
https://berkeley.zoom.us/
“Modeling immune-cancer interactions using a microfluidic 3D culture approach”
Charles Baroud, Ph.D.
Professor at Ecole Polytechnique, France
Lab Head at Institut Pasteur, Paris, France
Abstract:
Cancer immunotherapy is emerging as a transformative approach for treating cancer patients. This approach, which has shown some remarkable successes, leverages the patient’s own immune cells to locate and attack the tumor cells. However the method suffers from large heterogeneities in outcomes between different patients, in part due to the the number, phenotype, and distribution of cytotoxic T cells (CTLs) around the tumor cells. For this reason decoding the collective behavior of CTLs, as they recognize and attack cancer cells, is a major challenge that requires advanced in vitro models. This seminar will present a microfluidic platform that enables quantitative measurements of the spatiotemporal dynamics of individual CTLs as they migrate in three-dimensional (3D) environments and attack cancer spheroids. The method provides access to the trajectories of thousands of cells around hundreds of spheroids, which in turn enables probabilistic modeling of the trajectories. Analysis of the migration and killing events allows us to dissect the different phases of interactions and to identify limiting steps for different conditions. The talk will present the microfluidics and then shift focus to different biological models, with implications for both fundamental biology and for personalized medicine.
Wednesday March 8
12noon – 1:00pm
290 Hearst Mining Building
Siddharth Dey, UCSB
Wednesday, March 15
12noon – 1:00pm
290 Hearst Mining Building
Samira Musah, Duke University
Wednesday March 22
2022-23 Distinguished Lecture in Bioengineering
Professor Nancy Allbritton
Professor of Bioengineering and Frank & Julie Jungers Dean, College of Engineering, University of Washington
Details TBA
Wednesday, April 5
12noon – 1:00pm
290 Hearst Mining Building
or Register for Zoom link here:
https://berkeley.zoom.us/
“Discovering brain-behavior relationships using Motion Sequencing”
Sandeep Robert Datta, M.D., Ph.D.
Professor of Neurobiology
Harvard Medical School
Abstract:
The central challenge in neurobiology is to understand how the brain gives rise to behavior. However, we have limited tools to query the structure of complex, naturalistic behavior of the sort generated by animals in the wild. Here I will discuss methodologies we have developed that reveal the “syllables” and “grammar” out of which mouse behavior is organized, and our application of these approaches (including closed-loop methods) to better understand the neural basis for spontaneous action. I will both review recent progress in understanding brain-behavior relationships gleaned through these methods, and discuss recent technical advances that will propel this line of research forward in the future.
Wednesday, April 19
12noon – 1:00pm
290 Hearst Mining Building
Jeanne Stachowiak, University of Texas, Austin
Wednesday, April 19
12noon – 1:00pm
290 Hearst Mining Building
Nick Altemose, Stanford University
Don’t miss our annual Distinguished Lecture in Bioengineering on March 22 and Rising Star Lecture on February 22.
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