Biomaterials include living tissue and artificial materials used for the repair, replacement, and stimulation of biological systems. Nanotechnology involves the development and use of technologies that operate on the nanometer length scale, around the size of a large biomolecule. Exciting efforts are underway to combine these two areas to assemble materials from nanoscale building blocks.
Our faculty are working at the interface of these two fields, with applications ranging from stem cell culture platforms to bio-inspired coatings to surgical adhesives.
Faculty working in biomaterials & nanotechnology:Iain Clark
Assistant Professor, Bioengineeringhttp://clarklab.berkeley.edu/
The Clark Lab develops microfluidic and molecular methods for the high throughput analysis of single cells. We use these techniques to study HIV latency in CD4 T cells and profile cellular interactions during central nervous system inflammation.
Our work has been focused on establishing new paradigms in multi-tissue stem cell aging, rejuvenation and regulation by conserved morphogenic signaling pathways. One of our goals is to define pharmacology for enhancing maintenance and repair of adult tissues in vivo. The spearheaded by us heterochronic parabiosis and blood apheresis studies have established that the process of aging is reversible through modulation of circulatory milieu. Our synthetic biology method of choice focuses on bio-orthogonal non-canonical amino acid tagging (BONCAT) and subsequent identification of age-imposed and disease-causal changes in mammalian proteomes in vivo. Our drug delivery reg medicine projects focus on CRISPR/Cas9 based therapeutics for more effective and safer gene editing.
Montford G. Cook Professor, Bioengineering
Professor, Electrical Engineering & Computer Sciences
The Conolly Lab has built the world’s highest spatial resolution MPI scanner and the only projection MPI scanner in the world. In addition, the lab has built the only 3D Projection-Reconstruction MPI scanner currently in existence.
Assistant Professor, Bioengineering
The development of immunoengineering technologies to direct immune cell function. We build artificial lymph nodes, mRNA vaccines and 3D printed interfaces to study and control immune cell behaviour. These technologies have applications in cancer therapy, inducing transplant tolerance, spaceflight and auto-immune diseases.
Professor in Residence, Department of Bioengineering
Professor and Chair, Bioengineering and Therapeutic Sciences, UCSF
Dr. Desai’s lab focuses in the area of biomedical micro and nanotechnology for therapeutic delivery. Professor Desai’s research spans multiple disciplines including materials engineering, cell biology, tissue engineering, and drug delivery.
Chancellor’s Professor, Department of Chemistry;
Professor, Departments of Bioengineering, Chemical & Biomolecular Engineering
The simultaneous revolutions in energy, molecular biology, nanotechnology and advanced scientific computing, is giving rise to new interdisciplinary research opportunities in computational science. The Head-Gordon lab embraces this large scope of science drivers through development of computational models and methodologies applied to molecular liquids, macromolecular assemblies, protein biophysics, and homogeneous, heterogeneous catalysis and biocatalysis. The development and application of complex chemistry models, accelerated sampling methods, coarse graining/multiscale techniques, and machine learning developed in her lab are widely disseminated through many community software codes that scale on high performance computing platforms.
Jan Fandrianto Professor, Bioengineering
Professor, Materials Science & Engineering
Research in the Healy Lab emphasizes the relationship between materials and the cells or tissues they contact. The research program focuses on the design and synthesis of bioinspired materials that actively direct the fate of mammalian cells, and facilitate regeneration of damaged tissues and organs. Major discoveries from his laboratory have centered on the control of cell fate and tissue formation in contract with materials that are tunable in both their biological content and mechanical properties. Professor Healy also has extensive experience with human stem cell technologies, microphysiological systems, drug delivery systems, and novel bioconjugate therapeutics.
Adjunct Professor, Bioengineering
Chancellor’s Professor and Chair, Bioengineering
Professor of Chemical and Biomolecular Engineering
Professor in Residence, Bioengineering and Therapeutic Sciences, UCSF
Faculty Scientist, Biological Systems and Engineering, LBNL
Our lab seeks to understand and engineer mechanical and other biophysical communication between cells and materials. In addition to investigating fundamental aspects of this problem with a variety of micro/nanoscale technologies, we are especially interested in discovering how this signaling regulates tumor and stem cell biology in the central nervous system. Recent directions have included: (1) Engineering new tissue-mimetic culture platforms for biophysical studies, molecular analysis, and screening; (2) Exploring mechanobiological signaling systems as targets for limiting the invasion of brain tumors and enhancing stem cell neurogenesis; and (3) Creating new biomaterials inspired by cellular structural networks.
Bioengineering and Electrical Engineering & Computer Sciences
Dr. Lee’s research interests are biophotonics, quantum nanoplasmonics, in-vivo nanoscopy, single cell biophysics, quantitative systems biology, SERS, molecular diagnostics, BioMEMS, soft-state Biological Application Specific Integrated Circuits (BASICs), neural interfaces, and systematic neurological science and engineering by Biologically-inspired Photonics & Optofluidic Electronics Technology and Science (BioPOETS).
Faculty Scientist, Lawrence Berkeley National Laboratory
We are interested in bio-inspired nanomaterials and nanotechnology. We are developing new ways to fabricate high performance materials and devices through self-assembly processes by exploiting biological organisms such as viruses and cells. We are also designing synthetic viruses which can be exploited as regenerative tissue engineering materials and drug delivery vehicles.
Professor, Mechanical Engineering
BioMEMS, microfluid dynamics, experimental biofluid dynamics, hemodynamics associated with valvular heart disease and other cardiac and arterial flows.
Class of 1941 Endowed Professor of Bioengineering and Materials Science and Engineeringhttps://bioinspiredmaterials.berkeley.edu/
My laboratory is interested in understanding structure-property relationships in biological materials and in using this information to design biologically inspired materials for use in healthcare. Fundamental studies include single molecule and bulk biophysical studies of biointerfacial and bulk mechanochemical phenomena in biological materials, whereas our applied studies the design and synthesis of novel biomaterials for tissue repair and regeneration.
Professor, Mechanical Engineering
Faculty Scientist, Lawrence Berkeley National Lab
Our research program is focused on understanding cell mechanobiology and molecular mechanisms involved in human disease, in particular cardiovascular dysfunctions, brain and neurological disorders, and cancer.
Our laboratory is focused on developing new materials for drug delivery and molecular imaging.
Professor Emeritus, Bioengineering
Professor of the Graduate School, Mechanical Engineering
Bioelectronic devices, biotransport, medical imaging, electrical impedance tomography.
Professor, Chemical & Biomolecular Engineering, Bioengineering, and Molecular & Cell Biology
Director, Berkeley Stem Cell Center
Our research program melds basic biology and applied engineering principles to investigate preclinical and clinical gene and stem cell therapies, i.e. gene replacement and cell replacement approaches to treat human disease.