Please join us for a Spring Bioengineering Seminar

Professor Marc Dandin
Carnegie Mellon University

“Lab-on-CMOS Platforms for Cell Culture Monitoring and Drug Potency Studies”

April 30, 2025, 12:00 – 1:00 pm, 106 Stanley Hall

Abstract:
Lab-on-CMOS is a technology platform that combines miniaturized bioanalytical hardware with complementary metal-oxide semiconductor (CMOS) electronics to provide integrated biosensing in a compact format. In this talk, I will focus on a class of lab-on-CMOS systems that utilize capacitance sensing to monitor cell cultures, track cell proliferation, and observe other cell life-cycle events, such as mitosis. In this paradigm, changes in interfacial capacitance result from the activity of adherent cells at a capacitive bioelectronic interface, and these changes are monitored in real time to provide information about the cells. For system calibration, changes in capacitance are mapped to cell proliferation or life-cycle events using a ground-truth measurement, such as live-cell imaging from real-time microscopy. The talk will cover several layers of the technology stack, from device design and system integration to biology and cancer drug potency experiments. Lastly, I will discuss the outstanding instrumentation challenges that remain with lab-on-CMOS platforms.