Computational Biology

Recent news:

brain section image showing wide distribution of edited cells in the cortex

Could a new medical approach fix faulty genes before birth?

November 5, 2024

Murthy lab and UC Davis have developed a unique mRNA delivery method for in-utero gene editing for neurodevelopmental conditions.

Drawing of the LNPs encapsulating iGeoCas9 RNP

Thermostable Cas9 Enhances RNP Performance in Lung and Liver

November 5, 2024

Niren Murthy et al. have developed a more stable version of the Cas9 enzyme to improve delivery of CRISPR-Cas9 ribonucleoproteins (RNPs) for in vivo gene editing.

Faculty Focus on Leah Guthrie

October 10, 2024

Professor Leah Guthrie works to understand how the microbiome metabolites and proteins communicate with our human cells to influence our physiology and pathophysiology. Learn more about Guthrie in this interview with QB3.

MoA animation by Visual Science, 2024

Scientists Discover Next-Generation System for Programmable Genome Design

July 2, 2024

A team of researchers led by Professor Patrick Hsu has discovered the first DNA recombinase that is programmable, allowing the user to specify any desired genomic target sequence and any donor DNA molecule to be inserted. The bridge recombinase mechanism promises to expand genome editing beyond CRISPR and RNA interference (RNAi) to offer a unified mechanism for programmable DNA rearrangements. Bioengineering graduate student Nicholas Perry is also a lead author of the study, along with other researchers from the Arc Institute.

lareau

Liana Lareau wins Bakar Spark Award

May 21, 2024

Congratulations to Professor Liana Lareau, winner of a 2024 Spark Award from the Bakar Fellows Program.