Lab on a Chip
Recent news:
A team led by Professors Kevin Healy and Niren Murthy have developed a microfluidic heart-on-a-chip, with which they were able to discover a lipid nanoparticle that could penetrate the dense heart muscle and efficiently deliver its cargo of therapeutic mRNA into heart muscle cells. This new drug delivery method and testing platform may pave the way to new cardiac treatments.
Check out this video highlight of Professor Aaron Streets’ research, by the Pew Charitable Trust.
BioE postdoc Trinh Lam’s animated video explains how Herr Lab’s BlotSeq single-cell tool uses sequencing data to guide protein selection without the need to predefine targets, making the process more flexible.
Trinh Lam, a postdoc in Amy Herr’s lab, has won the Biomicrofluidics Best Paper Award from AIP Publishing at the 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences – Micro-Total Analysis Systems (µTAS 2024).
Professor Aaron Streets was featured in this overview on the potential of microfluidics in The Scientist magazine.
Patrick Hsu’s lab has developed an RNA-extraction-free test for rapid viral detection using saliva via a microfluidic device. The fast, accurate, and portable prototype shows potential as a point-of-care system to support frequent, on-site molecular diagnostics. This work was the August 2022 cover story for Nature Biomedical Engineering.
Professor Iain Clark, in partnership with graduate program faculty member Adam Abate, was able to analyze single cells harboring latent HIV using a technique that isolates single, infected cells as tiny amounts of blood move through their microfluidic devices. Their work was featured in Science news.
Cell interactions contribute to central nervous system pathology, but techniques to define these interactions are limited. In a publication in Science, Professor Iain Clark’s lab describes a new method that determines the molecular phenotypes and connections between cells in vivo. This technique allows them to identify new therapeutic targets that disrupt inflammatory crosstalk in experimental autoimmunity, and potentially, in neurologic disorders like Multiple Sclerosis.
Professor Aaron Streets’ lab has developed a novel technique for unraveling and imaging lengthy strands of DNA.