Faculty Focus on Leah Guthrie

Professor Leah Guthrie works to understand how the microbiome metabolites and proteins communicate with our human cells to influence our physiology and pathophysiology. Learn more about Guthrie in this interview with QB3.

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Revealing the Mysteries Within Microbial Genomes

The Boba-seq logo, created by former Arkin Lab undergraduate student researcher Davian Ho. A drawing of a large cup of boba tea, where the boba pearls represent expressed genes

Adam Arkin’s lab has developed a new technique, barcoded overexpression bacterial shotgun library sequencing (Boba-seq), that will make it much easier for researchers to discover the traits or activities encoded by genes of unknown function in microbes.

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Scientists Discover Next-Generation System for Programmable Genome Design

MoA animation by Visual Science, 2024

A team of researchers led by Professor Patrick Hsu has discovered the first DNA recombinase that is programmable, allowing the user to specify any desired genomic target sequence and any donor DNA molecule to be inserted. The bridge recombinase mechanism promises to expand genome editing beyond CRISPR and RNA interference (RNAi) to offer a unified mechanism for programmable DNA rearrangements. Bioengineering graduate student Nicholas Perry is also a lead author of the study, along with other researchers from the Arc Institute.

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