In a new paper in Nature Chemical Biology, Professor Adam Arkin and collaborator Vivek Mutalik report advances in understanding phage biology that bring us closer to using these small predators to fight antibiotic-resistant bacteria.
research
Conboy Lab awarded $3million by Open Philanthropy
Professor Irina Conboy has been awarded a $3 million grant from Open Philanthropy to continue her lab’s groundbreaking research in engineering longevity. Open Philanthropy is a privately funded grantmaker with a focus on Global Health & Wellbeing and Longtermism. The Conboy lab works to understand age-imposed and pathological changes in molecular compositions of systemic and […]
Finding solutions for living on Mars — and a rapidly changing Earth
Prof Adam Arkin and the Center for the Utilization of Biological Engineering in Space are leading efforts to create zero-waste biomanufacturing systems in “Mars-like conditions”, for human futures on other worlds and our own.
Streamlined detection of SARS-CoV-2 RNA in saliva
Patrick Hsu’s lab has developed an RNA-extraction-free test for rapid viral detection using saliva via a microfluidic device. The fast, accurate, and portable prototype shows potential as a point-of-care system to support frequent, on-site molecular diagnostics. This work was the August 2022 cover story for Nature Biomedical Engineering.
Old plasma dilution reduces human biological age
New work from Irina Conboy’s lab extends to humans their previous animal studies on age-specific differences in blood plasma, and establishes a novel direct measurement of biological age. Their results continue to demonstrate that aging may be driven by an excess of certain molecules and proteins, and point to potential treatments for age-related conditions.
Single-cell studies offer new view of how HIV infections persist
Professor Iain Clark, in partnership with graduate program faculty member Adam Abate, was able to analyze single cells harboring latent HIV using a technique that isolates single, infected cells as tiny amounts of blood move through their microfluidic devices. Their work was featured in Science news.
Transfusing blood from an old mouse to a younger mouse causes ageing
New research from the Conboy Lab, highlighted in New Scientist magazine, has demonstrated that transfusing young mice with blood from older rodents quickly triggers ageing in the young, suggesting that cellular ageing isn’t just a case of wear and tear. This is one step closer to potential anti-ageing treatments and builds on years of aging research from Professor Irina Conboy.
Human lung proteins can advance or thwart SARS-CoV-2 infections
A study led by Prof Patrick Hsu has identified specific proteins within our bodies that can promote or protect us from SARS-CoV-2 infections, potentially opening the door to new antiviral therapies. Notably, they showed that mucins — the main component of mucus found in the lungs — seem to help block the SARS-CoV-2 virus from entering cells.
Bacteria for Blastoff: Using Microbes to Make Supercharged New Rocket Fuel
New research led by Professor Jay Keasling took inspiration from an extraordinary antifungal molecule made by Streptomyces bacteria to develop a totally new type of fuel that has projected energy density greater than the most advanced heavy-duty fuels used today, including the rocket fuels used by NASA.