Patrick Hsu’s lab has developed an RNA-extraction-free test for rapid viral detection using saliva via a microfluidic device. The fast, accurate, and portable prototype shows potential as a point-of-care system to support frequent, on-site molecular diagnostics. This work was the August 2022 cover story for Nature Biomedical Engineering.
research
Old plasma dilution reduces human biological age
New work from Irina Conboy’s lab extends to humans their previous animal studies on age-specific differences in blood plasma, and establishes a novel direct measurement of biological age. Their results continue to demonstrate that aging may be driven by an excess of certain molecules and proteins, and point to potential treatments for age-related conditions.
Single-cell studies offer new view of how HIV infections persist
Professor Iain Clark, in partnership with graduate program faculty member Adam Abate, was able to analyze single cells harboring latent HIV using a technique that isolates single, infected cells as tiny amounts of blood move through their microfluidic devices. Their work was featured in Science news.
Transfusing blood from an old mouse to a younger mouse causes ageing
New research from the Conboy Lab, highlighted in New Scientist magazine, has demonstrated that transfusing young mice with blood from older rodents quickly triggers ageing in the young, suggesting that cellular ageing isn’t just a case of wear and tear. This is one step closer to potential anti-ageing treatments and builds on years of aging research from Professor Irina Conboy.
Human lung proteins can advance or thwart SARS-CoV-2 infections
A study led by Prof Patrick Hsu has identified specific proteins within our bodies that can promote or protect us from SARS-CoV-2 infections, potentially opening the door to new antiviral therapies. Notably, they showed that mucins — the main component of mucus found in the lungs — seem to help block the SARS-CoV-2 virus from entering cells.
Bacteria for Blastoff: Using Microbes to Make Supercharged New Rocket Fuel
New research led by Professor Jay Keasling took inspiration from an extraordinary antifungal molecule made by Streptomyces bacteria to develop a totally new type of fuel that has projected energy density greater than the most advanced heavy-duty fuels used today, including the rocket fuels used by NASA.
Researchers resolve riddle of mammalian brain’s navigation system
In a study published in Nature, a team of researchers in the lab of Professor Michael Yartsev studied neural activity in the hippocampus of freely flying bats and found that the neural codes remained unchanged over days and weeks. The discovery that these GPS-like neural codes remain stable over time has upended previous research and may further our understanding of diseases like Alzheimer’s.
Rempel leads study on electric vehicle charging stations
A study led by Professor Emeritus David Rempel and the environmental non-profit group Cool the Earth tested the functionality of 657 EVSE (electric vehicle service equipment) connectors at all 181 open public, non-Tesla charging stations in the Bay area. The study found that 27% were nonfunctional, a concerning issue for the widespread adoption of electric vehicles.
Solar beats nuclear at many potential settlement sites on Mars
Research by BioE PhD student Aaron Berliner and Prof Adam Arkin shows that photovoltaics could provide all the power needed for an extended mission to Mars, or even a permanent settlement there. The authors are members of the Center for the Utilization of Biological Engineering in Space (CUBES), led by Adam Arkin.