Niren Murthy
Professor, Bioengineering
Office Address: 312B Innovative Genomics Institute
Email: nmurthy@berkeley.edu
For more information, see: https://murthylab.berkeley.edu/
Research areas:
Biomaterials & Nanotechnology, Cell and Tissue Engineering
Our laboratory is focused on developing new materials for drug delivery and molecular imaging.
Education
- 2001 University of Washington in Seattle Ph.D Bioengineering
- 1996 University of Illinois at Chicago M.S. Bioengineering
- 1992 University of Redlands B.A. Political Science
Experience & Training
- 2012-present Professor, Department of Bioengineering, UC Berkeley
- 2008-2012 Associate Professor, Department of Biomedical Engineering, Georgia Tech/Emory University
- 2003 -2008 Assistant Professor, Department of Biomedical Engineering, Georgia Tech/Emory University
- 2001 – 2003 Postdoctoral Fellow, Department of Chemistry, U.C. Berkeley
- 1996 – 2001 Research Assistant, Department of Bioengineering, University of Washington
- 1994 – 1996 Research Assistant, Department of Bioengineering,UIC
Honors & Awards
- 2009 Society for Biomaterials Young Investigator Award
- 2008 Indus Global Innovators Award
- 2006 NSF CAREER AWARD
- 2003 Petit Fellowship: Received from the Georgia Institute of Technology
- 1998 Cygnus Outstanding graduate student award: Received from the Controlled Release Society
2024
Chen, Kai; Han, Hesong; Zhao, Sheng; Xu, Bryant; Yin, Boyan; Lawanprasert, Atip; Trinidad, Marena; Burgstone, Benjamin W.; Murthy, Niren; Doudna, Jennifer A.
Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 ribonucleoprotein Journal Article
In: NATURE BIOTECHNOLOGY, 2024, ISSN: 1087-0156.
@article{WOS:001335214700002,
title = {Lung and liver editing by lipid nanoparticle delivery of a stable
CRISPR-Cas9 ribonucleoprotein},
author = {Kai Chen and Hesong Han and Sheng Zhao and Bryant Xu and Boyan Yin and Atip Lawanprasert and Marena Trinidad and Benjamin W. Burgstone and Niren Murthy and Jennifer A. Doudna},
doi = {10.1038/s41587-024-02437-3},
issn = {1087-0156},
year = {2024},
date = {2024-10-01},
journal = {NATURE BIOTECHNOLOGY},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Qi, Yalin; Han, Hesong; Liu, Albert; Zhao, Sheng; Lawanprasert, Atip; Nielsen, Josefine Eilso; Choudhary, Hema; Liang, Dengpan; Barron, Annelise E.; Murthy, Niren
Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles Journal Article
In: RSC ADVANCES, vol. 14, no. 41, pp. 30071-30076, 2024.
@article{WOS:001316146700001,
title = {Ethylene oxide graft copolymers reduce the immunogenicity of lipid
nanoparticles},
author = {Yalin Qi and Hesong Han and Albert Liu and Sheng Zhao and Atip Lawanprasert and Josefine Eilso Nielsen and Hema Choudhary and Dengpan Liang and Annelise E. Barron and Niren Murthy},
doi = {10.1039/d4ra05007j},
year = {2024},
date = {2024-09-01},
journal = {RSC ADVANCES},
volume = {14},
number = {41},
pages = {30071-30076},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Zhao, Sheng; Gao, Kewa; Han, Hesong; Stenzel, Michael; Yin, Boyan; Song, Hengyue; Lawanprasert, Atip; Nielsen, Josefine Eilso; Sharma, Rohit; Arogundade, Opeyemi H.; Pimcharoen, Sopida; Chen, Yu-Ju; Paul, Abhik; Tuma, Jan; Collins, Michael G.; Wyle, Yofiel; Cranick, Matileen Grace; Burgstone, Benjamin W.; Perez, Barbara S.; Barron, Annelise E.; Smith, Andrew M.; Lee, Hye Young; Wang, Aijun; Murthy, Niren
Acid-degradable lipid nanoparticles enhance the delivery of mRNA Journal Article
In: NATURE NANOTECHNOLOGY, 2024, ISSN: 1748-3387.
@article{WOS:001296611100002,
title = {Acid-degradable lipid nanoparticles enhance the delivery of mRNA},
author = {Sheng Zhao and Kewa Gao and Hesong Han and Michael Stenzel and Boyan Yin and Hengyue Song and Atip Lawanprasert and Josefine Eilso Nielsen and Rohit Sharma and Opeyemi H. Arogundade and Sopida Pimcharoen and Yu-Ju Chen and Abhik Paul and Jan Tuma and Michael G. Collins and Yofiel Wyle and Matileen Grace Cranick and Benjamin W. Burgstone and Barbara S. Perez and Annelise E. Barron and Andrew M. Smith and Hye Young Lee and Aijun Wang and Niren Murthy},
doi = {10.1038/s41565-024-01765-4},
issn = {1748-3387},
year = {2024},
date = {2024-08-01},
journal = {NATURE NANOTECHNOLOGY},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Takemiya, Kiyoko; Wang, Shelly; Liu, Yu; Murthy, Niren; Goodman, Mark M.; Taylor, W. Robert
In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 695, 2024, ISSN: 0006-291X.
@article{WOS:001162031800001,
title = {Isothermal titration calorimetry analysis of the binding between the
maltodextrin binding protein malE of\textit{ Staphylococcus}\textit{ aureus}
with maltodextrins of various lengths},
author = {Kiyoko Takemiya and Shelly Wang and Yu Liu and Niren Murthy and Mark M. Goodman and W. Robert Taylor},
doi = {10.1016/j.bbrc.2023.149467},
issn = {0006-291X},
year = {2024},
date = {2024-02-01},
journal = {BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS},
volume = {695},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2023
Lyons, Danielle E.; Kumar, Priti; Roan, Nadia R.; Defechereux, Patricia A.; Feschotte, Cedric; Lange, Ulrike C.; Murthy, Niren; Sameshima, Pauline; Verdin, Eric; Ake, Julie A.; Parsons, Matthew S.; Nath, Avindra; Gianella, Sara; Smith, Davey M.; Kallas, Esper G.; Villa, Thomas J.; Strange, Richard; Mwesigwa, Betty; O'Brien, Robert L. Furler; Nixon, Douglas F.; Ndhlovu, Lishomwa C.; Valente, Susana T.; Ott, Melanie
HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing Journal Article
In: VIRUSES-BASEL, vol. 15, no. 11, 2023.
@article{WOS:001115345900001,
title = {HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing},
author = {Danielle E. Lyons and Priti Kumar and Nadia R. Roan and Patricia A. Defechereux and Cedric Feschotte and Ulrike C. Lange and Niren Murthy and Pauline Sameshima and Eric Verdin and Julie A. Ake and Matthew S. Parsons and Avindra Nath and Sara Gianella and Davey M. Smith and Esper G. Kallas and Thomas J. Villa and Richard Strange and Betty Mwesigwa and Robert L. Furler O'Brien and Douglas F. Nixon and Lishomwa C. Ndhlovu and Susana T. Valente and Melanie Ott},
doi = {10.3390/v15112171},
year = {2023},
date = {2023-11-01},
journal = {VIRUSES-BASEL},
volume = {15},
number = {11},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Tuma, Jan; Chen, Yu-Ju; Collins, Michael G.; Paul, Abhik; Li, Jie; Han, Hesong; Sharma, Rohit; Murthy, Niren; Lee, Hye Young
Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection Journal Article
In: BIOCHEMISTRY, vol. 62, no. 24, pp. 3533-3547, 2023, ISSN: 0006-2960.
@article{WOS:001125882400001,
title = {Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral
Injection},
author = {Jan Tuma and Yu-Ju Chen and Michael G. Collins and Abhik Paul and Jie Li and Hesong Han and Rohit Sharma and Niren Murthy and Hye Young Lee},
doi = {10.1021/acs.biochem.3c00371},
issn = {0006-2960},
year = {2023},
date = {2023-09-01},
journal = {BIOCHEMISTRY},
volume = {62},
number = {24},
pages = {3533-3547},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gao, Kewa; Li, Jie; Song, Hengyue; Han, Hesong; Wang, Yongheng; Yin, Boyan; Farmer, Diana L.; Murthy, Niren; Wang, Aijun
In utero delivery of mRNA to the heart, diaphragm and muscle with lipid nanoparticles Journal Article
In: BIOACTIVE MATERIALS, vol. 25, pp. 387-398, 2023.
@article{WOS:000946330200001,
title = {In utero delivery of mRNA to the heart, diaphragm and muscle with lipid
nanoparticles},
author = {Kewa Gao and Jie Li and Hengyue Song and Hesong Han and Yongheng Wang and Boyan Yin and Diana L. Farmer and Niren Murthy and Aijun Wang},
doi = {10.1016/j.bioactmat.2023.02.011},
year = {2023},
date = {2023-07-01},
journal = {BIOACTIVE MATERIALS},
volume = {25},
pages = {387-398},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bajaj, Teena; Wehri, Eddie; Suryawanshi, Rahul K.; King, Elizabeth; Pardeshi, Kundan Singh; Behrouzi, Kamyar; Khodabakhshi, Zahra; Schulze-Gahmen, Ursula; Kumar, G. Renuka; Mofrad, Mohammad R. K.; Nomura, Daniel K.; Ott, Melanie; Schaletzky, Julia; Murthy, Niren
Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication Journal Article
In: RSC ADVANCES, vol. 13, no. 26, pp. 17667-17677, 2023.
@article{WOS:001006972100001,
title = {Mercapto-pyrimidines are reversible covalent inhibitors of the
papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication},
author = {Teena Bajaj and Eddie Wehri and Rahul K. Suryawanshi and Elizabeth King and Kundan Singh Pardeshi and Kamyar Behrouzi and Zahra Khodabakhshi and Ursula Schulze-Gahmen and G. Renuka Kumar and Mohammad R. K. Mofrad and Daniel K. Nomura and Melanie Ott and Julia Schaletzky and Niren Murthy},
doi = {10.1039/d3ra01915b},
year = {2023},
date = {2023-06-01},
journal = {RSC ADVANCES},
volume = {13},
number = {26},
pages = {17667-17677},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Han, Hesong; Gracia, Albert Vallejo; Roise, Joachim J.; Boike, Lydia; Leon, Kristoffer; Schulze-Gahmen, Ursula; Stentzel, Michael R.; Bajaj, Teena; Chen, Dake; Li, I. -Che; He, Maomao; Behrouzi, Kamyar; Khodabakhshi, Zahra; Nomura, Daniel K.; Mofrad, Mohammad R. K.; Kumar, G. Renuka; Ott, Melanie; Murthy, Niren
A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication Journal Article
In: RSC ADVANCES, vol. 13, no. 16, pp. 10636-10641, 2023.
@article{WOS:000964370800001,
title = {A covalent inhibitor targeting the papain-like protease from SARS-CoV-2
inhibits viral replication},
author = {Hesong Han and Albert Vallejo Gracia and Joachim J. Roise and Lydia Boike and Kristoffer Leon and Ursula Schulze-Gahmen and Michael R. Stentzel and Teena Bajaj and Dake Chen and I. -Che Li and Maomao He and Kamyar Behrouzi and Zahra Khodabakhshi and Daniel K. Nomura and Mohammad R. K. Mofrad and G. Renuka Kumar and Melanie Ott and Niren Murthy},
doi = {10.1039/d3ra00426k},
year = {2023},
date = {2023-04-01},
journal = {RSC ADVANCES},
volume = {13},
number = {16},
pages = {10636-10641},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sellers, Drew L.; Lee, Kunwoo; Murthy, Niren; Pun, Suzie H.
TAxI-peptide targeted Cas12a ribonuclease protein nanoformulations increase genome editing in hippocampal neurons Journal Article
In: JOURNAL OF CONTROLLED RELEASE, vol. 354, pp. 188-195, 2023, ISSN: 0168-3659.
@article{WOS:000963150500001,
title = {TAxI-peptide targeted Cas12a ribonuclease protein nanoformulations
increase genome editing in hippocampal neurons},
author = {Drew L. Sellers and Kunwoo Lee and Niren Murthy and Suzie H. Pun},
doi = {10.1016/j.jconrel.2022.12.057},
issn = {0168-3659},
year = {2023},
date = {2023-02-01},
journal = {JOURNAL OF CONTROLLED RELEASE},
volume = {354},
pages = {188-195},
keywords = {},
pubstate = {published},
tppubtype = {article}
}