Arkin lab harnesses incredible bacterial ‘Homing Missiles’

artist image of a tailocin

Adam Arkin’s lab is leading research to harness tailocins – protein machines made by bacteria that are able to target and attack very specific strains of bacteria. They hope to understand and use these natural spring-powered microneedles to study the microbiome, and eventually to attack and treat harmful infections.

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TotalVI: A transformative algorithm

aaron streets

Researchers co-led by Professor Aaron Streets have invented a computer algorithm that uses deep learning to integrate gene and protein data about single cells that were gathered from different tissues and donors and were processed in different labs. Part of a global effort to build a Human Cell Atlas (HCA), the new algorithm will allow integration of data from different types of experiments to compile detailed protein information.

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Lareau helps detect more infectious COVID variant at Berkeley

COVID evolutionary tree

Professor Liana Lareau has been co-leading the Innovative Genomics Institute effort to monitor mutations in the SARS-CoV-2 virus in the local community. The team’s rapid sequencing turnaround is crucial for tracking the spread of new variants, including the more infectious B.1.1.7 recently detected in two cases at Berkeley.

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How water helps the substrate into the enzyme

photo of water droplet

An international research team including Professor Teresa Head-Gordon have investigated why cages can increase the catalytic activity of enclosed molecules. Using terahertz spectroscopy and complex computer simulations, they showed that water encapsulated in a tiny cage has special properties that are structurally and dynamically distinct from any known phase of water.

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