Iain Clark
Assistant Professor, Bioengineering
Office Address: 374 Stanley Hall
Email: iain.c.clark@berkeley.edu
For more information, see: http://clarklab.berkeley.edu/
Office hours: Tuesday 1-2:00 pm in 374 Stanley Hall
Research areas:
Bioinstrumentation, Biomaterials & Nanotechnology, Systems and Synthetic Biology
The Clark Lab develops microfluidic and molecular methods for the high throughput analysis of single cells. We use these techniques to study HIV latency in CD4 T cells and profile cellular interactions during central nervous system inflammation.
Education
- 2014 PhD Environmental Engineering, UC Berkeley
- 2009 MS Biosystems Engineering, UC Davis
- 2003 BS Biological Engineering, Cornell University
Experience & Training
- 2015-2020 Postdoc, Bioengineering, UCSF
- 2017-2020 Fellow, Harvard Medical School
Honors & Awards
- 2019 Women’s Brain Initiative Fellow, BWH, Harvard
- 2009 NSF Graduate Student Fellowship
2024
Peretz, Cheryl A. C.; Kennedy, Vanessa E.; Walia, Anushka; Delley, Cyrille L.; Koh, Andrew; Tran, Elaine; Clark, Iain C.; Hayford, Corey E.; D'Amato, Chris; Xue, Yi; Fontanez, Kristina M.; May-Zhang, Aaron A.; Smithers, Trinity; Agam, Yigal; Wang, Qian; Dai, Hai-ping; Roy, Ritu; Logan, Aaron C.; Perl, Alexander E.; Abate, Adam; Olshen, Adam; Smith, Catherine C.
Multiomic single cell sequencing identifies stemlike nature of mixed phenotype acute leukemia Journal Article
In: NATURE COMMUNICATIONS, vol. 15, no. 1, 2024.
@article{WOS:001315990000017,
title = {Multiomic single cell sequencing identifies stemlike nature of mixed
phenotype acute leukemia},
author = {Cheryl A. C. Peretz and Vanessa E. Kennedy and Anushka Walia and Cyrille L. Delley and Andrew Koh and Elaine Tran and Iain C. Clark and Corey E. Hayford and Chris D'Amato and Yi Xue and Kristina M. Fontanez and Aaron A. May-Zhang and Trinity Smithers and Yigal Agam and Qian Wang and Hai-ping Dai and Ritu Roy and Aaron C. Logan and Alexander E. Perl and Adam Abate and Adam Olshen and Catherine C. Smith},
doi = {10.1038/s41467-024-52317-2},
year = {2024},
date = {2024-09-01},
journal = {NATURE COMMUNICATIONS},
volume = {15},
number = {1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lee, Hong-Gyun; Rone, Joseph M.; Li, Zhaorong; Akl, Camilo Faust; Shin, Seung Won; Lee, Joon-Hyuk; Flausino, Lucas E.; Pernin, Florian; Chao, Chun-Cheih; Kleemann, Kilian L.; Srun, Lena; Illouz, Tomer; Giovannoni, Federico; Charabati, Marc; Sanmarco, Liliana M.; Kenison, Jessica E.; Piester, Gavin; Zandee, Stephanie E. J.; Antel, Jack P.; Rothhammer, Veit; Wheeler, Michael A.; Prat, Alexandre; Clark, Iain C.; Quintana, Francisco J.
Disease-associated astrocyte epigenetic memory promotes CNS pathology Journal Article
In: NATURE, vol. 627, no. 8005, pp. 865+, 2024, ISSN: 0028-0836.
@article{WOS:001252470200001,
title = {Disease-associated astrocyte epigenetic memory promotes CNS pathology},
author = {Hong-Gyun Lee and Joseph M. Rone and Zhaorong Li and Camilo Faust Akl and Seung Won Shin and Joon-Hyuk Lee and Lucas E. Flausino and Florian Pernin and Chun-Cheih Chao and Kilian L. Kleemann and Lena Srun and Tomer Illouz and Federico Giovannoni and Marc Charabati and Liliana M. Sanmarco and Jessica E. Kenison and Gavin Piester and Stephanie E. J. Zandee and Jack P. Antel and Veit Rothhammer and Michael A. Wheeler and Alexandre Prat and Iain C. Clark and Francisco J. Quintana},
doi = {10.1038/s41586-024-07187-5},
issn = {0028-0836},
year = {2024},
date = {2024-03-01},
journal = {NATURE},
volume = {627},
number = {8005},
pages = {865+},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2023
Clark, Iain C.; Fontanez, Kristina M.; Meltzer, Robert H.; Xue, Yi; Hayford, Corey; May-Zhang, Aaron; D'Amato, Chris; Osman, Ahmad; Zhang, Jesse Q.; Hettige, Pabodha; Ishibashi, Jacob S. A.; Delley, Cyrille L.; Weisgerber, Daniel W.; Replogle, Joseph M.; Jost, Marco; Phong, Kiet T.; Kennedy, Vanessa E.; Peretz, Cheryl A. C.; Kim, Esther A.; Song, Siyou; Karlon, William; Weissman, Jonathan S.; Smith, Catherine C.; Gartner, Zev J.; Abate, Adam R.
Microfluidics-free single-cell genomics with templated emulsification Journal Article
In: NATURE BIOTECHNOLOGY, vol. 41, no. 11, pp. 1557+, 2023, ISSN: 1087-0156.
@article{WOS:000944128100001,
title = {Microfluidics-free single-cell genomics with templated emulsification},
author = {Iain C. Clark and Kristina M. Fontanez and Robert H. Meltzer and Yi Xue and Corey Hayford and Aaron May-Zhang and Chris D'Amato and Ahmad Osman and Jesse Q. Zhang and Pabodha Hettige and Jacob S. A. Ishibashi and Cyrille L. Delley and Daniel W. Weisgerber and Joseph M. Replogle and Marco Jost and Kiet T. Phong and Vanessa E. Kennedy and Cheryl A. C. Peretz and Esther A. Kim and Siyou Song and William Karlon and Jonathan S. Weissman and Catherine C. Smith and Zev J. Gartner and Adam R. Abate},
doi = {10.1038/s41587-023-01685-z},
issn = {1087-0156},
year = {2023},
date = {2023-11-01},
journal = {NATURE BIOTECHNOLOGY},
volume = {41},
number = {11},
pages = {1557+},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wheeler, Michael A.; Clark, Iain C.; Lee, Hong-Gyun; Li, Zhaorong; Linnerbauer, Mathias; Rone, Joseph M.; Blain, Manon; Akl, Camilo Faust; Piester, Gavin; Giovannoni, Federico; Charabati, Marc; Lee, Joon-Hyuk; Kye, Yoon-Chul; Choi, Joshua; Sanmarco, Liliana M.; Srun, Lena; Chung, Elizabeth N.; Flausino, Lucas E.; Andersen, Brian M.; Rothhammer, Veit; Yano, Hiroshi; Illouz, Tomer; Zandee, Stephanie E. J.; Daniel, Carolin; Artis, David; Prinz, Marco; Abate, Adam R.; Kuchroo, Vijay K.; Antel, Jack P.; Prat, Alexandre; Quintana, Francisco J.
Droplet-based forward genetic screening of astrocyte-microglia cross-talk Journal Article
In: SCIENCE, vol. 379, no. 6636, pp. 1023-1030, 2023, ISSN: 0036-8075.
@article{WOS:000982417000009,
title = {Droplet-based forward genetic screening of astrocyte-microglia
cross-talk},
author = {Michael A. Wheeler and Iain C. Clark and Hong-Gyun Lee and Zhaorong Li and Mathias Linnerbauer and Joseph M. Rone and Manon Blain and Camilo Faust Akl and Gavin Piester and Federico Giovannoni and Marc Charabati and Joon-Hyuk Lee and Yoon-Chul Kye and Joshua Choi and Liliana M. Sanmarco and Lena Srun and Elizabeth N. Chung and Lucas E. Flausino and Brian M. Andersen and Veit Rothhammer and Hiroshi Yano and Tomer Illouz and Stephanie E. J. Zandee and Carolin Daniel and David Artis and Marco Prinz and Adam R. Abate and Vijay K. Kuchroo and Jack P. Antel and Alexandre Prat and Francisco J. Quintana},
doi = {10.1126/science.abq4822},
issn = {0036-8075},
year = {2023},
date = {2023-03-01},
journal = {SCIENCE},
volume = {379},
number = {6636},
pages = {1023-1030},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Clark, Iain C.; Mudvari, Prakriti; Thaploo, Shravan; Smith, Samuel; Abu-Laban, Mohammad; Hamouda, Mehdi; Theberge, Marc; Shah, Sakshi; Ko, Sung Hee; Perez, Liliana; Bunis, Daniel G.; Lee, James S. S.; Kilam, Divya; Zakaria, Saami; Choi, Sally; Darko, Samuel; Henry, Amy R.; Wheeler, Michael A.; Hoh, Rebecca; Butrus, Salwan; Deeks, Steven G.; Quintana, Francisco J.; Douek, Daniel C.; Abate, Adam R.; Boritz, Eli A.
HIV silencing and cell survival signatures in infected T cell reservoirs Journal Article
In: NATURE, vol. 614, no. 7947, 2023, ISSN: 0028-0836.
@article{WOS:000952315900008,
title = {HIV silencing and cell survival signatures in infected T cell reservoirs},
author = {Iain C. Clark and Prakriti Mudvari and Shravan Thaploo and Samuel Smith and Mohammad Abu-Laban and Mehdi Hamouda and Marc Theberge and Sakshi Shah and Sung Hee Ko and Liliana Perez and Daniel G. Bunis and James S. S. Lee and Divya Kilam and Saami Zakaria and Sally Choi and Samuel Darko and Amy R. Henry and Michael A. Wheeler and Rebecca Hoh and Salwan Butrus and Steven G. Deeks and Francisco J. Quintana and Daniel C. Douek and Adam R. Abate and Eli A. Boritz},
doi = {10.1038/s41586-022-05556-6},
issn = {0028-0836},
year = {2023},
date = {2023-02-01},
journal = {NATURE},
volume = {614},
number = {7947},
keywords = {},
pubstate = {published},
tppubtype = {article}
}