Patrick Hsu
![hsu24 photo of Patrick Hsu standing in laboratory](https://bioeng.berkeley.edu/wp-content/uploads/hsu24.png)
Assistant Professor, Bioengineering
Office Address: 512E IGI
Email: pdhsu@berkeley.edu
For more information, see: http://patrickhsulab.org/
Office hours: 512E IGI, by appointment via Zoom email pdhsu@berkeley.edu
Research areas:
Computational Biology, Systems and Synthetic Biology
The Hsu Lab aims to understand and manipulate the genetic circuits that control brain and immune cell function to improve human health. We explore the rich biological diversity of nature to create new molecular technologies, perturb complex cellular processes at scale, and develop next-generation gene and cell therapies. To do this, our group draws from a palette of experimental and computational techniques including CRISPR-Cas systems, single cell genomics, engineered viruses, brain organoids, and pooled genetic screens. Current interests include 1) inventing novel approaches for editing the postmitotic genome, 2) developing engineered vehicles for therapeutic macromolecule delivery, and 3) leveraging library screens and brain organoids to interrogate human neuroscience at scale.
Education
- 2014 Ph.D. Biochemistry, Harvard University
- 2013 A.M. Biology, Harvard University
- 2010 B.A. Molecular and Cell Biology, magna cum laude, University of California, Berkeley
Experience & Training
- 2022 – present Co-Founder and Core Investigator, Arc Institute
- 2019 – Present Assistant Professor of Bioengineering and Deb Faculty Fellow, University of California, Berkeley
- 2016 – 2019 Principal Investigator and Salk Faculty Fellow, Salk Institute for Biological Studies; La Jolla, CA
- 2014 – 2015 Group Leader, Editas Medicine
Other positions:
- 2017 – Present Editorial Board, The CRISPR Journal
Honors & Awards
- 2021 Amgen Young Investigator Award
- 2020 Rose Hill Innovator
- 2020 In Vivo’s 30 Rising Leaders of 2020
- 2019 Rainwater Prize for Innovative Early-Career Scientists
- 2019 Deb Faculty Fellow, Berkeley Engineering
- 2019 MIT Technology Review Innovators Under 35
- 2015-2019 NIH Director’s Early Independence Award
- 2015 Salk-Helmsley Faculty Fellow
- 2015 Forbes 30 Under 30
- 2015 Community Value Award, Editas Medicine
- 2014 Harvard Chinese Life Science Annual Distinguished Research Award
- 2014 Harvard Merit Fellow, Harvard University
- 2010-2013 James Mills Pierce Fellow, Harvard University
- 2010 Outstanding Honors Award, Department of Molecular & Cellular Biology, University of California, Berkeley
- 2009 Helen Tomasini Merit Scholar, University of California, Berkeley
2024
Durrant, Matthew G.; Perry, Nicholas T.; Pai, James J.; Jangid, Aditya R.; Athukoralage, Januka S.; Hiraizumi, Masahiro; McSpedon, John P.; Pawluk, April; Nishimasu, Hiroshi; Konermann, Silvana; Hsu, Patrick D.
Bridge RNAs direct programmable recombination of target and donor DNA Journal Article
In: NATURE, vol. 630, no. 8018, 2024, ISSN: 0028-0836.
@article{WOS:001262531200018,
title = {Bridge RNAs direct programmable recombination of target and donor DNA},
author = {Matthew G. Durrant and Nicholas T. Perry and James J. Pai and Aditya R. Jangid and Januka S. Athukoralage and Masahiro Hiraizumi and John P. McSpedon and April Pawluk and Hiroshi Nishimasu and Silvana Konermann and Patrick D. Hsu},
doi = {10.1038/s41586-024-07552-4},
issn = {0028-0836},
year = {2024},
date = {2024-06-01},
journal = {NATURE},
volume = {630},
number = {8018},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hiraizumi, Masahiro; Perry, Nicholas T.; Durrant, Matthew G.; Soma, Teppei; Nagahata, Naoto; Okazaki, Sae; Athukoralage, Januka S.; Isayama, Yukari; Pai, James J.; Pawluk, April; Konermann, Silvana; Yamashita, Keitaro; Hsu, Patrick D.; Nishimasu, Hiroshi
Structural mechanism of bridge RNA-guided recombination Journal Article
In: NATURE, vol. 630, no. 8018, 2024, ISSN: 0028-0836.
@article{WOS:001262531200016,
title = {Structural mechanism of bridge RNA-guided recombination},
author = {Masahiro Hiraizumi and Nicholas T. Perry and Matthew G. Durrant and Teppei Soma and Naoto Nagahata and Sae Okazaki and Januka S. Athukoralage and Yukari Isayama and James J. Pai and April Pawluk and Silvana Konermann and Keitaro Yamashita and Patrick D. Hsu and Hiroshi Nishimasu},
doi = {10.1038/s41586-024-07570-2},
issn = {0028-0836},
year = {2024},
date = {2024-06-01},
journal = {NATURE},
volume = {630},
number = {8018},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2023
Wei, Jingyi; Lotfy, Peter; Faizi, Kian; Baungaard, Sara; Gibson, Emily; Wang, Eleanor; Slabodkin, Hannah; Kinnaman, Emily; Chandrasekaran, Sita; Kitano, Hugo; Durrant, Matthew G.; Duffy, Connor V; Pawluk, April; Hsu, Patrick D.; Konermann, Silvana
Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting Journal Article
In: CELL SYSTEMS, vol. 14, no. 12, 2023, ISSN: 2405-4712.
@article{WOS:001147275900001,
title = {Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA
targeting},
author = {Jingyi Wei and Peter Lotfy and Kian Faizi and Sara Baungaard and Emily Gibson and Eleanor Wang and Hannah Slabodkin and Emily Kinnaman and Sita Chandrasekaran and Hugo Kitano and Matthew G. Durrant and Connor V Duffy and April Pawluk and Patrick D. Hsu and Silvana Konermann},
doi = {10.1016/j.cels.2023.11.006},
issn = {2405-4712},
year = {2023},
date = {2023-12-01},
journal = {CELL SYSTEMS},
volume = {14},
number = {12},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Strine, Madison S.; Cai, Wesley L.; Wei, Jin; Alfajaro, Mia Madel; Filler, Renata B.; Biering, Scott B.; Sarnik, Sylvia; Chow, Ryan D.; Patil, Ajinkya; Cervantes, Kasey S.; Collings, Clayton K.; DeWeirdt, Peter C.; Hanna, Ruth E.; Schofield, Kevin; Hulme, Christopher; Konermann, Silvana; Doench, John G.; Hsu, Patrick D.; Kadoch, Cigall; Yan, Qin; Wilen, Craig B.
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner Journal Article
In: PLOS BIOLOGY, vol. 21, no. 6, 2023, ISSN: 1544-9173.
@article{WOS:001010559000001,
title = {DYRK1A promotes viral entry of highly pathogenic human coronaviruses in
a kinase-independent manner},
author = {Madison S. Strine and Wesley L. Cai and Jin Wei and Mia Madel Alfajaro and Renata B. Filler and Scott B. Biering and Sylvia Sarnik and Ryan D. Chow and Ajinkya Patil and Kasey S. Cervantes and Clayton K. Collings and Peter C. DeWeirdt and Ruth E. Hanna and Kevin Schofield and Christopher Hulme and Silvana Konermann and John G. Doench and Patrick D. Hsu and Cigall Kadoch and Qin Yan and Craig B. Wilen},
doi = {10.1371/journal.pbio.3002097},
issn = {1544-9173},
year = {2023},
date = {2023-06-01},
journal = {PLOS BIOLOGY},
volume = {21},
number = {6},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Durrant, Matthew G.; Fanton, Alison; Tycko, Josh; Hinks, Michaela; Chandrasekaran, Sita S.; Perry, Nicholas T.; Schaepe, Julia; Du, Peter P.; Lotfy, Peter; Bassik, Michael C.; Bintu, Lacramioara; Bhatt, Ami S.; Hsu, Patrick D.
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome Journal Article
In: NATURE BIOTECHNOLOGY, vol. 41, no. 4, pp. 488+, 2023, ISSN: 1087-0156.
@article{WOS:000865706400006,
title = {Systematic discovery of recombinases for efficient integration of large
DNA sequences into the human genome},
author = {Matthew G. Durrant and Alison Fanton and Josh Tycko and Michaela Hinks and Sita S. Chandrasekaran and Nicholas T. Perry and Julia Schaepe and Peter P. Du and Peter Lotfy and Michael C. Bassik and Lacramioara Bintu and Ami S. Bhatt and Patrick D. Hsu},
doi = {10.1038/s41587-022-01494-w},
issn = {1087-0156},
year = {2023},
date = {2023-04-01},
journal = {NATURE BIOTECHNOLOGY},
volume = {41},
number = {4},
pages = {488+},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dmello, Crismita; Zhao, Junfei; Chen, Li; Gould, Andrew; Castro, Brandyn; Arrieta, Victor A.; Zhang, Daniel Y.; Kim, Kwang-Soo; Kanojia, Deepak; Zhang, Peng; Miska, Jason; Yeeravalli, Ragini; Habashy, Karl; Saganty, Ruth; Kang, Seong Jae; Fares, Jawad; Liu, Connor; Dunn, Gavin; Bartom, Elizabeth; Schipma, Matthew J.; Hsu, Patrick D.; Alghamri, Mahmoud S.; Lesniak, Maciej S.; Heimberger, Amy B.; Rabadan, Raul; Lee-Chang, Catalina; Sonabend, Adam M.
Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade Journal Article
In: NATURE COMMUNICATIONS, vol. 14, no. 1, 2023.
@article{WOS:001063479500003,
title = {Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune
response and sensitizes gliomas to immune checkpoint blockade},
author = {Crismita Dmello and Junfei Zhao and Li Chen and Andrew Gould and Brandyn Castro and Victor A. Arrieta and Daniel Y. Zhang and Kwang-Soo Kim and Deepak Kanojia and Peng Zhang and Jason Miska and Ragini Yeeravalli and Karl Habashy and Ruth Saganty and Seong Jae Kang and Jawad Fares and Connor Liu and Gavin Dunn and Elizabeth Bartom and Matthew J. Schipma and Patrick D. Hsu and Mahmoud S. Alghamri and Maciej S. Lesniak and Amy B. Heimberger and Raul Rabadan and Catalina Lee-Chang and Adam M. Sonabend},
doi = {10.1038/s41467-023-36878-2},
year = {2023},
date = {2023-03-01},
journal = {NATURE COMMUNICATIONS},
volume = {14},
number = {1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2022
Chandrasekaran, Sita S.; Agrawal, Shreeya; Fanton, Alison; Jangid, Aditya R.; Charrez, Berenice; Escajeda, Arturo M.; Son, Sungmin; Mcintosh, Roger; Tran, Huyen; Bhuiya, Abdul; de Leon Derby, Maria Diaz; Switz, Neil A.; Armstrong, Maxim; Harris, Andrew R.; Prywes, Noam; Lukarska, Maria; Biering, Scott B.; Smock, Dylan C. J.; Mok, Amanda; Knott, Gavin J.; Dang, Qi; Dis, Erik Van; Dugan, Eli; Kim, Shin; Liu, Tina Y.; Consortium, Igi Testing; Moehle, Erica A.; Kogut, Katherine; Eskenazi, Brenda; Harris, Eva; Stanley, Sarah A.; Lareau, Liana F.; Tan, Ming X.; Fletcher, Daniel A.; Doudna, Jennifer A.; Savage, David F.; Hsu, Patrick D.
Rapid detection of SARS-CoV-2 RNA in saliva via Cas13 Journal Article
In: NATURE BIOMEDICAL ENGINEERING, vol. 6, no. 8, pp. 944+, 2022, ISSN: 2157-846X.
@article{WOS:000839493700002,
title = {Rapid detection of SARS-CoV-2 RNA in saliva via Cas13},
author = {Sita S. Chandrasekaran and Shreeya Agrawal and Alison Fanton and Aditya R. Jangid and Berenice Charrez and Arturo M. Escajeda and Sungmin Son and Roger Mcintosh and Huyen Tran and Abdul Bhuiya and Maria Diaz de Leon Derby and Neil A. Switz and Maxim Armstrong and Andrew R. Harris and Noam Prywes and Maria Lukarska and Scott B. Biering and Dylan C. J. Smock and Amanda Mok and Gavin J. Knott and Qi Dang and Erik Van Dis and Eli Dugan and Shin Kim and Tina Y. Liu and Igi Testing Consortium and Erica A. Moehle and Katherine Kogut and Brenda Eskenazi and Eva Harris and Sarah A. Stanley and Liana F. Lareau and Ming X. Tan and Daniel A. Fletcher and Jennifer A. Doudna and David F. Savage and Patrick D. Hsu},
doi = {10.1038/s41551-022-00917-y},
issn = {2157-846X},
year = {2022},
date = {2022-08-01},
journal = {NATURE BIOMEDICAL ENGINEERING},
volume = {6},
number = {8},
pages = {944+},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Biering, Scott B.; Sarnik, Sylvia A.; Wang, Eleanor; Zengel, James R.; Leist, Sarah R.; Schafer, Alexandra; Sathyan, Varun; Hawkins, Padraig; Okuda, Kenichi; Tau, Cyrus; Jangid, Aditya R.; Duffy, Connor V; Wei, Jin; Gilmore, Rodney C.; Alfajaro, Mia Madel; Strine, Madison S.; Nguyenla, Xammy; Dis, Erik Van; Catamura, Carmelle; Yamashiro, Livia H.; Belk, Julia A.; Begeman, Adam; Stark, Jessica C.; Shon, D. Judy; Fox, Douglas M.; Ezzatpour, Shahrzad; Huang, Emily; Olegario, Nico; Rustagi, Arjun; Volmer, Allison S.; Livraghi-Butrico, Alessandra; Wehri, Eddie; Behringer, Richard R.; Cheon, Dong-Joo; Schaletzky, Julia; Aguilar, Hector C.; Puschnik, Andreas S.; Button, Brian; Pinsky, Benjamin A.; Blish, Catherine A.; Baric, Ralph S.; O'Neal, Wanda K.; Bertozzi, Carolyn R.; Wilen, Craig B.; Boucher, Richard C.; Carette, Jan E.; Stanley, Sarah A.; Harris, Eva; Konermann, Silvana; Hsu, Patrick D.
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection Journal Article
In: NATURE GENETICS, vol. 54, no. 8, pp. 1078+, 2022, ISSN: 1061-4036.
@article{WOS:000829717200003,
title = {Genome-wide bidirectional CRISPR screens identify mucins as host factors
modulating SARS-CoV-2 infection},
author = {Scott B. Biering and Sylvia A. Sarnik and Eleanor Wang and James R. Zengel and Sarah R. Leist and Alexandra Schafer and Varun Sathyan and Padraig Hawkins and Kenichi Okuda and Cyrus Tau and Aditya R. Jangid and Connor V Duffy and Jin Wei and Rodney C. Gilmore and Mia Madel Alfajaro and Madison S. Strine and Xammy Nguyenla and Erik Van Dis and Carmelle Catamura and Livia H. Yamashiro and Julia A. Belk and Adam Begeman and Jessica C. Stark and D. Judy Shon and Douglas M. Fox and Shahrzad Ezzatpour and Emily Huang and Nico Olegario and Arjun Rustagi and Allison S. Volmer and Alessandra Livraghi-Butrico and Eddie Wehri and Richard R. Behringer and Dong-Joo Cheon and Julia Schaletzky and Hector C. Aguilar and Andreas S. Puschnik and Brian Button and Benjamin A. Pinsky and Catherine A. Blish and Ralph S. Baric and Wanda K. O'Neal and Carolyn R. Bertozzi and Craig B. Wilen and Richard C. Boucher and Jan E. Carette and Sarah A. Stanley and Eva Harris and Silvana Konermann and Patrick D. Hsu},
doi = {10.1038/s41588-022-01131-x},
issn = {1061-4036},
year = {2022},
date = {2022-08-01},
journal = {NATURE GENETICS},
volume = {54},
number = {8},
pages = {1078+},
keywords = {},
pubstate = {published},
tppubtype = {article}
}