Aaron Streets
Associate Professor, Bioengineering
Office Address: 608 Stanley Hall
Email: astreets@berkeley.edu
For more information, see: https://streetslab.com/
Office hours: Mon 4:00 - 5:00 pm, 608 Stanley
Research areas:
Bioinstrumentation, Computational Biology, Systems and Synthetic Biology
The Streets lab is interested in applying lessons from mathematics, physics, and engineering, to invent tools that help us dissect and quantify complex biological systems. Our goal is to uncover laws that govern the interactions of molecules inside the cell and the interactions between cells in a tissue or organism, by making precision measurements on single cells. In pursuit of this goal, we exploit three core technologies; microfluidics, microscopy, and genomics.
Education
-
2012 Ph.D., Applied Physics, Stanford University
-
2004 B.S. magna cum laude, Physics, University of California, Los Angeles
-
2004 B.A. magna cum laude, Art, University of California, Los Angeles
Experience & Training
- 2022 – present Associate Professor, Department of Bioengineering, University of California, Berkeley
- 2016 – 2022 Assistant Professor, Department of Bioengineering, University of California, Berkeley
- 2016 President’s Postdoctoral Fellow, University of California, San Francisco
- 2012-2016 Postdoctoral research scholar, Peking University, Biodynamic Optical Imaging Center (BIOPIC)
Honors & Awards
- 2021 UC Bioengineering Systemwide Shu Chien Early Career Award
- 2019 NSF CAREER award
- 2019 Pew Biomedical Scholar
- 2017-2021 Chan Zuckerberg Biohub Investigator
- 2015 UC President’s Postdoctoral Fellow
- 2014 Peking University Outstanding Postdoctoral Scholar
- 2014 Ford Foundation Postdoctoral Fellow
- 2011 Whitaker International Biomedical Engineering Scholar
- 2009-2011 Stanford Vice Provost for Graduate Education Diversifying Academia and Recruiting Excellence (DARE) Fellowship
2024
Gayoso, Adam; Weiler, Philipp; Lotfollahi, Mohammad; Klein, Dominik; Hong, Justin; Streets, Aaron; Theis, Fabian J.; Yosef, Nir
Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells Journal Article
In: NATURE METHODS, vol. 21, no. 1, 2024, ISSN: 1548-7091.
@article{WOS:001142480100003,
title = {Deep generative modeling of transcriptional dynamics for RNA velocity
analysis in single cells},
author = {Adam Gayoso and Philipp Weiler and Mohammad Lotfollahi and Dominik Klein and Justin Hong and Aaron Streets and Fabian J. Theis and Nir Yosef},
doi = {10.1038/s41592-023-01994-w},
issn = {1548-7091},
year = {2024},
date = {2024-01-01},
journal = {NATURE METHODS},
volume = {21},
number = {1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2023
Gayoso, Adam; Weiler, Philipp; Lotfollahi, Mohammad; Klein, Dominik; Hong, Justin; Streets, Aaron; Theis, Fabian J.; Yosef, Nir
Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells Journal Article
In: NATURE METHODS, 2023, ISSN: 1548-7091.
@article{WOS:001073433300001,
title = {Deep generative modeling of transcriptional dynamics for RNA velocity
analysis in single cells},
author = {Adam Gayoso and Philipp Weiler and Mohammad Lotfollahi and Dominik Klein and Justin Hong and Aaron Streets and Fabian J. Theis and Nir Yosef},
doi = {10.1038/s41592-023-01994},
issn = {1548-7091},
year = {2023},
date = {2023-09-01},
journal = {NATURE METHODS},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Vasic, Ivana; Libby, Ashley R. G.; Maslan, Annie; Bulger, Emily A.; Zalazar, David; Compagno, Martina Z. Krakora; Streets, Aaron; Tomoda, Kiichiro; Yamanaka, Shinya; Mcdevitt, Todd C.
Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells Journal Article
In: DEVELOPMENTAL CELL, vol. 58, no. 16, 2023, ISSN: 1534-5807.
@article{WOS:001062937000001,
title = {Loss of TJP1 disrupts gastrulation patterning and increases
differentiation toward the germ cell lineage in human pluripotent stem
cells},
author = {Ivana Vasic and Ashley R. G. Libby and Annie Maslan and Emily A. Bulger and David Zalazar and Martina Z. Krakora Compagno and Aaron Streets and Kiichiro Tomoda and Shinya Yamanaka and Todd C. Mcdevitt},
doi = {10.1016/j.devcel.2023.05.019},
issn = {1534-5807},
year = {2023},
date = {2023-08-01},
journal = {DEVELOPMENTAL CELL},
volume = {58},
number = {16},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Steier, Zoe; Aylard, Dominik A.; McIntyre, Laura L.; Baldwin, Isabel; Kim, Esther Jeong Yoon; Lutes, Lydia K.; Ergen, Can; Huang, Tse-Shun; Robey, Ellen A.; Yosef, Nir; Streets, Aaron
Single-cell multiomic analysis of thymocyte development reveals drivers of CD4<SUP>+</SUP> T cell and CD8<SUP>+</SUP> T cell lineage commitment Journal Article
In: NATURE IMMUNOLOGY, 2023, ISSN: 1529-2908.
@article{WOS:001048132600002,
title = {Single-cell multiomic analysis of thymocyte development reveals drivers
of CD4<SUP>+</SUP> T cell and CD8<SUP>+</SUP> T cell lineage commitment},
author = {Zoe Steier and Dominik A. Aylard and Laura L. McIntyre and Isabel Baldwin and Esther Jeong Yoon Kim and Lydia K. Lutes and Can Ergen and Tse-Shun Huang and Ellen A. Robey and Nir Yosef and Aaron Streets},
doi = {10.1038/s41590-023-01584-0},
issn = {1529-2908},
year = {2023},
date = {2023-08-01},
journal = {NATURE IMMUNOLOGY},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gupta, Anushka; Efthymiou, Vissarion; Kodani, Sean D.; Shamsi, Farnaz; Patti, Mary Elizabeth; Tseng, Yu-Hua; Streets, Aaron
Mapping the transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seq Journal Article
In: MOLECULAR METABOLISM, vol. 74, 2023, ISSN: 2212-8778.
@article{WOS:001038645700001,
title = {Mapping the transcriptional landscape of human white and brown
adipogenesis using single-nuclei RNA-seq},
author = {Anushka Gupta and Vissarion Efthymiou and Sean D. Kodani and Farnaz Shamsi and Mary Elizabeth Patti and Yu-Hua Tseng and Aaron Streets},
doi = {10.1016/j.molmet.2023.101746},
issn = {2212-8778},
year = {2023},
date = {2023-08-01},
journal = {MOLECULAR METABOLISM},
volume = {74},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Cao, Xiaobao; Buryska, Tomas; Yang, Tianjin; Wang, Jing; Fischer, Peter; Streets, Aaron; Stavrakis, Stavros; deMello, Andrew
Towards an active droplet-based microfluidic platform for programmable fluid handling Journal Article
In: LAB ON A CHIP, vol. 23, no. 8, pp. 2029-2038, 2023, ISSN: 1473-0197.
@article{WOS:000960992400001,
title = {Towards an active droplet-based microfluidic platform for programmable
fluid handling},
author = {Xiaobao Cao and Tomas Buryska and Tianjin Yang and Jing Wang and Peter Fischer and Aaron Streets and Stavros Stavrakis and Andrew deMello},
doi = {10.1039/d3lc00015j},
issn = {1473-0197},
year = {2023},
date = {2023-04-01},
journal = {LAB ON A CHIP},
volume = {23},
number = {8},
pages = {2029-2038},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2022
Zhang, Xinyi; Dorlhiac, Gabriel; Landry, Markita P.; Streets, Aaron
Phototoxic effects of nonlinear optical microscopy on cell cycle, oxidative states, and gene expression Journal Article
In: SCIENTIFIC REPORTS, vol. 12, no. 1, 2022, ISSN: 2045-2322.
@article{WOS:000879722100038,
title = {Phototoxic effects of nonlinear optical microscopy on cell cycle,
oxidative states, and gene expression},
author = {Xinyi Zhang and Gabriel Dorlhiac and Markita P. Landry and Aaron Streets},
doi = {10.1038/s41598-022-23054-7},
issn = {2045-2322},
year = {2022},
date = {2022-11-01},
journal = {SCIENTIFIC REPORTS},
volume = {12},
number = {1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Chen, Tao; Cao, Chen; Zhang, Jianyun; Streets, Aaron; Li, Tiejun; Huang, Yanyi
Histologically resolved multiomics enables precise molecular profiling of human intratumor heterogeneity Journal Article
In: PLOS BIOLOGY, vol. 20, no. 7, 2022, ISSN: 1544-9173.
@article{WOS:000926478900012,
title = {Histologically resolved multiomics enables precise molecular profiling
of human intratumor heterogeneity},
author = {Tao Chen and Chen Cao and Jianyun Zhang and Aaron Streets and Tiejun Li and Yanyi Huang},
doi = {10.1371/journal.pbio.3001699},
issn = {1544-9173},
year = {2022},
date = {2022-07-01},
journal = {PLOS BIOLOGY},
volume = {20},
number = {7},
keywords = {},
pubstate = {published},
tppubtype = {article}
}