 | Daniel A. FletcherPurnendu Chatterjee Chair in Engineering Biological Systems, Department of Bioengineering |
Research Interests
My laboratory studies the mechanics and dynamics of cell movements on the purified protein, single cell, and tissue levels. For these studies, we are developing new instruments to quantify cell and molecular mechanics based on optical microscopy, force microscopy, and microfabrication.
Education
2002 Postdoctoral Fellow, Stanford University, Biochemistry
2001 Ph.D., Stanford University, Mechanical Engineering
1997 D.Phil., Oxford University, Engineering Science
1994 B.S.E., Princeton University, Mechanical & Aerospace Engineering
Major Awards
2010 Bioengineering Teaching Award, Outstanding Instructor, Bioengineering Honor Society, UC Berkeley
2010 Tech Award Laureate, Museum of Technology and Innovation, San Jose, CA
2009 Bill and Melinda Gates Foundation Grand Challenges Exploration Grant
2009 Vodafone Americas Foundation Wireless Innovation Project
2009 Intel Inspire Empower Challenge for Healthcare
2008-2009 White House Fellow, Washington, DC
2008 Vodafone Wireless Innovation Challenge
2008 Intel Inspire-Empower Challenge
2005 Hellman Faculty Fund Award, UC Berkeley
2004 National Science Foundation CAREER Award
2004 National Collegiate Inventors and Innovators E-Team Award
2003 UC Berkeley Presidential Chair Fellow
2001 National Inventors Hall of Fame Collegiate Inventors Award
1996 National Science Foundation Graduate Research Fellowship
1995 American Society of Mechanical Engineering Arthur L. Williston Medal
1994 Rhodes Scholarship
Professional Experience
2011-present Associate Chair, Department of Bioengineering, UC Berkeley
2010-present Professor, Bioengineering, UC Berkeley
2007-present Deputy Division Director, Physical Biosciences, Lawrence Berkeley National Lab
2007-2010 Associate Professor, Bioengineering, UC Berkeley
2002-2007 Assistant Professor, Bioengineering, UC Berkeley
2003-present Faculty Scientist, Physical Biosciences, Lawrence Berkeley National Laboratory
2003-present Member, Nanoscale Science & Engineering Graduate Group, UC Berkeley
2002-present Member, Bioengineering Graduate Group, UC Berkeley & UCSF
2002-present Member, Biophysics Graduate Group, UC Berkeley
2002-present Faculty Affiliate, QB3, UC Berkeley
Selected Publications
Crow A, Webster KD, Hohlfeld E, Ng WP, Geissler P, Fletcher DA. Contractile equilibriation of single cells to step changes in extracellular stiffness. Biophys J. 2012 Feb 8;102(3):443-51. Epub 2012 Feb 7.
Risca VI, Wang EB, Chaudhuri O, Chia JJ, Geissler PL, Fletcher DA. Actin filament curvature biases branching direction. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2913-8. Epub 2012 Jan 30.
Tsai M, Kita A, Leach J, Rounsevell R, Huang JN, Moake J, Ware RE, Fletcher DA, Lam WA. In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology. J Clin Invest. 2012 Jan 3;122(1):408-18. doi: 10.1172/JCI58753. Epub 2011 Dec 12.
Kita A, Sakuri Y, Myers DR, Rounsevell R, Huang JN, Seok TJ, Yu K, Wu MC, Fletcher DA, Lam WA. Microenvironmental geometry guides platelet adhesion and spreading: A quantitative analysis at the single cell level. PLoS One. 2011;6(10):e26437. Epub 2011 Oct 20.
Richmond DL, Schmid EM, Martens S, Stachowiak JC, Liska N, Fletcher DA. Forming giant vesicles with controlled membrane composition, asymmetry, and contents. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9431-6. Epub 2011 May 18.
Webster KD, Crow A, Fletcher DA. An AFM-based stiffness clamp for dynamic control of rigidity. PLoS ONE. 2011 Mar 8;6(3):e17807.
