Department Faculty

Daniel A. Fletcher

Purnendu Chatterjee Chair in Engineering Biological Systems, Department of Bioengineering
Faculty Scientist, Lawrence Berkeley National Laboratory
Deputy Division Director, Physical Biosciences Division, LBL

608B Stanley Hall
mailcode: 1762
(510) 643-5624
fax: 510-664-4115
ude.yelekrebnull@hctelf
http://fletchlab.berkeley.edu

Research Interests


My laboratory studies the mechanics and dynamics of cell movements on the purified protein, single cell, and tissue levels.  For these studies, we are developing new instruments to quantify cell and molecular mechanics based on optical microscopy, force microscopy, and microfabrication.

Education

2002    Postdoctoral Fellow, Stanford University, Biochemistry
2001    Ph.D., Stanford University, Mechanical Engineering
1997    D.Phil., Oxford University, Engineering Science
1994    B.S.E., Princeton University, Mechanical & Aerospace Engineering

Major Awards

2010 Bioengineering Teaching Award, Outstanding Instructor, Bioengineering Honor Society, UC Berkeley

2010 Tech Award Laureate, Museum of Technology and Innovation, San Jose, CA

2009 Bill and Melinda Gates Foundation Grand Challenges Exploration Grant

2009 Vodafone Americas Foundation Wireless Innovation Project

2009 Intel Inspire Empower Challenge for Healthcare

2008-2009   White House Fellow, Washington, DC

2008           Vodafone Wireless Innovation Challenge

2008           Intel Inspire-Empower Challenge

2005           Hellman Faculty Fund Award, UC Berkeley

2004           National Science Foundation CAREER Award

2004           National Collegiate Inventors and Innovators E-Team Award

2003           UC Berkeley Presidential Chair Fellow

2001           National Inventors Hall of Fame Collegiate Inventors Award

1996           National Science Foundation Graduate Research Fellowship

1995           American Society of Mechanical Engineering Arthur L. Williston Medal

1994           Rhodes Scholarship

Professional Experience

2011-present    Associate Chair, Department of Bioengineering, UC Berkeley

2010-present    Professor, Bioengineering, UC Berkeley

2007-present    Deputy Division Director, Physical Biosciences, Lawrence Berkeley National Lab

2007-2010        Associate Professor, Bioengineering, UC Berkeley  

2002-2007        Assistant Professor, Bioengineering, UC Berkeley

2003-present    Faculty Scientist, Physical Biosciences, Lawrence Berkeley National Laboratory

2003-present    Member, Nanoscale Science & Engineering Graduate Group, UC Berkeley

2002-present    Member, Bioengineering Graduate Group, UC Berkeley & UCSF

2002-present    Member, Biophysics Graduate Group, UC Berkeley

2002-present    Faculty Affiliate, QB3, UC Berkeley

Selected Publications

Crow A, Webster KD, Hohlfeld E, Ng WP, Geissler P, Fletcher DA. Contractile equilibriation of single cells to step changes in extracellular stiffness. Biophys J. 2012 Feb 8;102(3):443-51. Epub 2012 Feb 7.

Risca VI, Wang EB, Chaudhuri O, Chia JJ, Geissler PL, Fletcher DA. Actin filament curvature biases branching direction. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2913-8. Epub 2012 Jan 30.

Tsai M, Kita A, Leach J, Rounsevell R, Huang JN, Moake J, Ware RE, Fletcher DA, Lam WA. In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology. J Clin Invest. 2012 Jan 3;122(1):408-18. doi: 10.1172/JCI58753. Epub 2011 Dec 12.

Kita A, Sakuri Y, Myers DR, Rounsevell R, Huang JN, Seok TJ, Yu K, Wu MC, Fletcher DA, Lam WA. Microenvironmental geometry guides platelet adhesion and spreading: A quantitative analysis at the single cell level. PLoS One. 2011;6(10):e26437. Epub 2011 Oct 20.

Richmond DL, Schmid EM, Martens S, Stachowiak JC, Liska N, Fletcher DA. Forming giant vesicles with controlled membrane composition, asymmetry, and contents. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9431-6. Epub 2011 May 18.

Webster KD, Crow A, Fletcher DA. An AFM-based stiffness clamp for dynamic control of rigidity. PLoS ONE. 2011 Mar 8;6(3):e17807.